Evidence map›Paper›PMID 24088959›Full record

ReviewKidney international2014

Lineage-tracing methods and the kidney.

Benjamin D Humphreys, Derek P DiRocco

Open access · bronzeAbstract readReview
In one paragraph

Review in Kidney international, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 39 citations in OpenAlex.

  1. Article
  2. Rodent models of AKI and AKI-CKD transition: an update in 2024.American journal of physiology. Renal physiology · 2024
    Review
  3. Review
  4. Review
  5. Short-term effects of mechanical loading on the transdifferentiation of condylar chondrocytes.American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics · 2023
    Article
  6. Article
  7. Potential renal stem/progenitor cells identified by in vivo lineage tracing.American journal of physiology. Renal physiology · 2022
    Review
  8. Article
  9. Review
  10. Review
  11. Review
  12. Single Cell Sequencing and Kidney Organoids Generated from Pluripotent Stem Cells.Clinical journal of the American Society of Nephrology : CJASN · 2020
    Review
  13. Article
  14. Article
  15. Co-localization of Cell Lineage Markers and the Tomato Signal.Journal of visualized experiments : JoVE · 2016
    Article
  16. Article
  17. Review
  18. Cutting to the chase: taking the pulse of label-retaining cells in kidney.American journal of physiology. Renal physiology · 2015
    Article
  19. Review
  20. Development and Diseases of the Collecting Duct System.Results and problems in cell differentiation
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Benjamin D Humphreys1] Renal Division, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA [2] Harvard Medical School, Boston, Massachusetts, USA [3] Harvard Stem Cell Institute, Cambridge, Massachusetts, USA.
Derek P DiRocco1] Renal Division, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA [2] Harvard Medical School, Boston, Massachusetts, USA.
Harvard Stem Cell Institute · USHarvard University · US

Funding

Hedgehog Signaling in Kidney Homeostasis and RepairR01DK088923 · NIDDK · BRIGHAM AND WOMEN'S HOSPITAL · PI HUMPHREYS, BENJAMIN D. · 2010 to 2014
$2.0M
NIDDK NIH HHS DK088923NIDDK NIH HHS R01 DK088923
6 · The paper itself

Abstract

The kidney is a complex organ with over 30 different cell types, and understanding the lineage relationships between these cells is challenging. During nephrogenesis, a central question is how the coordinated morphogenesis, growth, and differentiation of distinct cell types leads to development of a functional organ. In mature kidney, understanding cell division and fate during injury, regeneration and aging are critical topics for understanding disease. Genetic lineage tracing offers a powerful tool to decipher cellular hierarchies in both development and disease because it allows the progeny of a single cell, or group of cells, to be tracked unambiguously. Recent advances in this field include the use of inducible recombinases, multicolor reporters, and mosaic analysis. In this review, we discuss lineage-tracing methods focusing on the mouse model system and consider the impact of these methods on our understanding of kidney biology and prospects for future application.

Indexed as

Cell LineageAnimalsGene ExpressionGenes, ReporterGenetic TechniquesKidneyMiceRecombinasesRecombination, GeneticRecombinases

Identifiers

PMID24088959
PMCPMC3975825
OpenAlexW2003196914

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.