ReviewKidney international2014
Kidney xenotransplantation.
Review in Kidney international, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed.
- Publication Trends of Research on Immune Tolerance After Kidney Transplantation: A Bibliometric Analysis from 1976 to 2024.Journal of multidisciplinary healthcare · 2026Article
- Perceptions and Attitudes of Muslims in Israel When Using Porcine-Based Organs in Transplantation Procedures.Journal of religion and health · 2025Article
- Characterizing coagulation responses in humans and nonhuman primates following kidney xenotransplantation-A narrative review.American journal of hematology · 2025Review
- Genetically modified pigs with α1,3-galactosyltransferase knockout and beyond: a comprehensive review of xenotransplantation strategies.Frontiers in immunology · 2025Review
- Research prospects for kidney xenotransplantation: a bibliometric analysis.Renal failure · 2024Article
- Human PD-L1 overexpression decreases xenogeneic human T-cell immune responses towards porcine kidneys.Frontiers in immunology · 2024Article
- Transitioning of renal transplant pathology from allograft to xenograft and tissue engineering pathology: Are we prepared?World journal of transplantation · 2023Review
- Effects of human TFPI and CD47 expression and selectin and integrin inhibition during GalTKO.hCD46 pig lung perfusion with human blood.Xenotransplantation · 2022Article
- Xenotransplantation: A New Era.Frontiers in immunology · 2022Review
- Long-term survival of pig-to-rhesus macaque renal xenografts is dependent on CD4 T cell depletion.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2019Article
- Recapitulating kidney development: Progress and challenges.Seminars in cell & developmental biology · 2019Review
- Thromboxane and histamine mediate PVR elevation during xenogeneic pig lung perfusion with human blood.Xenotransplantation · 2019Article
- Potential Antigens Involved in Delayed Xenograft Rejection in a Ggta1/Cmah Dko Pig-to-Monkey Model.Scientific reports · 2017Article
- Selection of Patients for Initial Clinical Trials of Solid Organ Xenotransplantation.Transplantation · 2017Review
- Reducing the Threshold for Clinical Renal Xenotransplantation.Transplantation · 2017Article
- Heterotopic Renal Autotransplantation in a Porcine Model: A Step-by-Step Protocol.Journal of visualized experiments : JoVE · 2016Article
- The need for xenotransplantation as a source of organs and cells for clinical transplantation.International journal of surgery (London, England) · 2015Review
- Pigs pave a way to de novo formation of functional human kidneys.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- The case for xenotransplantation.Clinical transplantation · 2015Article
- Bortezomib, C1-inhibitor and plasma exchange do not prolong the survival of multi-transgenic GalT-KO pig kidney xenografts in baboons.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Xenotransplantation using pigs as donors offers the possibility of eliminating the chronic shortage of donor kidneys, but there are several obstacles to be overcome before this goal can be achieved. Preclinical studies have shown that, while porcine renal xenografts are broadly compatible physiologically, they provoke a complex rejection process involving preformed and elicited antibodies, heightened innate immune cell reactivity, dysregulated coagulation, and a strong T cell-mediated adaptive response. Furthermore, the susceptibility of the xenograft to proinflammatory and procoagulant stimuli is probably increased by cross-species molecular defects in regulatory pathways. To balance these disadvantages, xenotransplantation has at its disposal a unique tool to address particular rejection mechanisms and incompatibilities: genetic modification of the donor. This review focuses on the pathophysiology of porcine renal xenograft rejection, and on the significant genetic, pharmacological, and technical progress that has been made to prolong xenograft survival.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.