ArticleJournal of clinical microbiology2013
wzi Gene sequencing, a rapid method for determination of capsular type for Klebsiella strains.
Article in Journal of clinical microbiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 231 papers.
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Who cites it
231 citing papers in PubMed.
- Wzi modulates immune evasion of hypervirulentVirulence · 2026Article
- Molecular Insights Into Hypervirulent Klebsiella pneumoniae: Identification and Correlation of Virulence Determinant.MicrobiologyOpen · 2026Article
- Receptor Structure Shapes Host Range but Incompletely Predicts High Activity inAntibiotics (Basel, Switzerland) · 2026Article
- The Evolving Clonal, Plasmid-Mediated Resistome, Virulome and Therapeutic Landscape of Carbapenem-ResistantAntibiotics (Basel, Switzerland) · 2026Article
- Isolation and characterization of phage vB_KpnS_SXK7 against multidrug-resistant Klebsiella pneumoniae and the mechanism of O-antigen-associated phage resistance.BMC microbiology · 2026Article
- Molecular characterization and pathogenicity of Klebsiella pneumoniae species complex associated with mass mortality of Oncorhynchus mykiss in the Ladakh trans-himalayas.Scientific reports · 2026Article
- A review on hypervirulent and multidrug-resistant Klebsiella pneumoniae: An emerging threat to human health.Naunyn-Schmiedeberg's archives of pharmacology · 2026Review
- Comparative genomic, phenotypic, and clinical characterization of ST11-KL25 and ST11-KL64 hypervirulent carbapenem-resistantAntimicrobial agents and chemotherapy · 2026Article
- Targeting carbapenem-resistant and hypervirulent Klebsiella pneumoniae: in vitro evaluation of cefepime/zidebactam, aztreonam/avibactam, imipenem/relebactam, and meropenem/vaborbactam.BMC infectious diseases · 2026Article
- Genotypes, antibiotic resistance, and virulence diversity among Klebsiella pneumoniae species complex isolates in Taiwan.Gut pathogens · 2026Article
- Hospital outbreak sustained byEuro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2026Article
- Isolation, characterization, and therapeutic assessment of novel phage vB_LSKP32 targeting KL64-type carbapenem-resistant Klebsiella pneumoniae.Archives of virology · 2026Article
- Shifting of blaBMC genomics · 2026Article
- The sero-prevalence and virulence determinants ofMicrobiology spectrum · 2026Article
- Characterization of the bacteriophage vB_KpnP_Henu1_3 lytic for K1Microbiology spectrum · 2026Article
- Hospital-adapted inhaled phage therapy for ventilator-associated pneumonia caused by multidrug-resistant Klebsiella pneumoniae: a comparative pilot study.Critical care (London, England) · 2026Article
- Recurrent Urinary Tract Infection Caused by Multidrug-ResistantCase reports in infectious diseases · 2026Article
- Overcoming phagocytosis resistance of hypervirulentMicrobial cell (Graz, Austria) · 2026Article
- Retrospective single-center study of endogenous endophthalmitis, Northeastern China, 2010-2023.Frontiers in cellular and infection microbiology · 2026Article
- An ISFrontiers in microbiology · 2026Article
171 more citing papers are in PubMed but not listed here.
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7 authors.
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Abstract
Pathogens of the genus Klebsiella have been classified into distinct capsular (K) types for nearly a century. K typing of Klebsiella species still has important applications in epidemiology and clinical microbiology, but the serological method has strong practical limitations. Our objective was to evaluate the sequencing of wzi, a gene conserved in all capsular types of Klebsiella pneumoniae that codes for an outer membrane protein involved in capsule attachment to the cell surface, as a simple and rapid method for the prediction of K type. The sequencing of a 447-nucleotide region of wzi distinguished the K-type reference strains with only nine exceptions. A reference wzi sequence database was created by the inclusion of multiple strains representing K types associated with high virulence and multidrug resistance. A collection of 119 prospective clinical isolates of K. pneumoniae were then analyzed in parallel by wzi sequencing and classical K typing. Whereas K typing achieved typeability for 81% and discrimination for 94.4% of the isolates, these figures were 98.1% and 98.3%, respectively, for wzi sequencing. The prediction of K type once the wzi allele was known was 94%. wzi sequencing is a rapid and simple method for the determination of the K types of most K. pneumoniae clinical isolates.
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