ArticleFly
Parasitoid wasp virulence: A window into fly immunity.
Article in Fly. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 24 citations in OpenAlex.
- Host-Associated Differentiation in a Parasitoid Wasp Connected to Venom-Related but Not Chemosensory Genes.Molecular ecology · 2026Article
- A bacterial gene acquired by parasitoid wasps contributes to venom secretion against host defence.The EMBO journal · 2026Article
- Article
- Serotonergic neurons regulate the Drosophila vascular niche to control immune stress hematopoiesis.Nature communications · 2025Article
- Venom vesicles from the parasitoidbioRxiv : the preprint server for biology · 2025Article
- Four Neurotoxic Insecticides Impair Partner and Host Finding in the Parasitoid Leptopilina heterotoma and Bioactive Doses Can Be Taken up Via the Host.Journal of chemical ecology · 2025Article
- Advanced biology students' individual conceptions of scientific researchers after participating in biomedically relevant CRE.Journal of microbiology & biology education · 2024Article
- Host JAK-STAT activity is a target of parasitoid wasp virulence strategies.PLoS pathogens · 2024Article
- TheEcology and evolution · 2023Review
- The S1A protease family membersmicroPublication biology · 2021Article
- Immune Cell Production Is Targeted by Parasitoid Wasp Virulence in aPathogens (Basel, Switzerland) · 2021Article
- Optimization of native biocontrol agents, with parasitoids of the invasive pestEvolutionary applications · 2018Review
- Article
- Independent origins of resistance or susceptibility of parasitic wasps to a defensive symbiont.Ecology and evolution · 2016Article
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In nature, larvae of the fruit fly Drosophila melanogaster are commonly infected by parasitoid wasps. Following infection, flies mount an immune response termed cellular encapsulation in which fly immune cells form a multilayered capsule that covers and kills the wasp egg. Parasitoids have thus evolved virulence factors to suppress cellular encapsulation. To uncover the molecular mechanisms underlying the antiwasp response, we and others have begun identifying and functionally characterizing these virulence factors. Our recent work on the Drosophila parasitoid Ganaspis sp.1 has demonstrated that a virulence factor encoding a SERCA-type calcium pump plays an important role in Ganaspis sp.1 virulence. This venom SERCA antagonizes fly immune cell calcium signaling and thereby prevents the activation of the encapsulation response. In this way, the study of wasp virulence factors has revealed a novel aspect of fly immunity, namely a role for calcium signaling in fly immune cell activation, which is conserved with human immunity, again illustrating the marked conservation between fly and mammalian immune responses. Our findings demonstrate that the cellular encapsulation response can serve as a model of immune cell function and can also provide valuable insight into basic cell biological processes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.