Evidence map›Paper›PMID 24088622›Full record

ArticleThe Journal of cardiovascular nursing

The link of unintentional weight loss to cardiac event-free survival in patients with heart failure.

Eun Kyeung Song, Yongjik Lee, Debra K Moser, Rebecca L Dekker, Seok-Min Kang, Terry A Lennie

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of cardiovascular nursing. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 3 pooled it
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 3 syntheses or guidelines pooled it, 26 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Weight Loss in Obese Patients With Heart Failure.Journal of the American Heart Association · 2016
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 2 countries.

Eun Kyeung SongEun Kyeung Song, PhD, RN Assistant Professor, Department of Nursing, College of Medicine, University of Ulsan, Korea. Yongjik Lee, MD Assistant Professor, Department of Thoracic and Cardiovascular Surgery, College of Medicine, University of Ulsan, Ulsan University Hospital, Korea. Debra K. Moser, DNSc, RN Professor, College of Nursing, University of Kentucky, Lexington. Rebecca L. Dekker, PhD, APRN Assistant Professor, College of Nursing, University of Kentucky, Lexington. Seok-Min Kang, MD, PhD Professor, Cardiology Division, Severance Hospital, Yonsei Cardiovascular Center and Cardiovascular Research Institute, Seoul, Korea. Terry A. Lennie, PhD, RN Professor, College of Nursing, University of Kentucky, Lexington.
Yongjik Lee
Debra K Moser
Rebecca L Dekker
Seok-Min Kang
Terry A Lennie
U.S. National Science Foundation · US

Funding

Cognitive Therapy for Depressive Symptoms in Hospitalized Patients with Heart FaiK23NR013480 · NINR · UNIVERSITY OF KENTUCKY · PI DEKKER, REBECCA · 2012 to 2014
$356k
NINR NIH HHS K23 NR013480
6 · The paper itself

Abstract

backgroundPatients with heart failure (HF) commonly have unintentional weight loss, depressive symptoms, and elevated levels of high-sensitivity C-reactive protein (hsCRP). Each of these variables has been independently associated with shorter cardiac event-free survival. However, little data exist on the relationships of unintentional weight loss, hsCRP level, and depressive symptoms to cardiac event-free survival.

objectiveThe aims of this study were to determine (1) whether depressive symptoms and elevated hsCRP level predicted unintentional weight loss and (2) whether unintentional weight loss predicted shorter cardiac event-free survival.

methodsThis was a prospective study of 243 consecutive HF patients (61% men, 61 ± 14 years old) enrolled during an index hospitalization for HF exacerbation. Patients provided blood samples to measure hsCRP level and completed the Beck Depression Inventory to assess depressive symptoms at discharge. Body weight was measured at discharge and 6 months later. Unintentional weight loss was defined as weight loss of greater than 6% of body weight since discharge. Cardiac event-free survival was followed for 1 year after the second measurement of body weight through monthly telephone interviews. Hierarchical logistic regression was used to determine whether depressive symptoms and elevated hsCRP level predicted unintentional weight loss. Cox hazard regression was used to determine whether unintentional weight loss predicted cardiac event-free survival.

resultsThirty-five patients (14.4%) experienced unintentional weight loss at 6 months after discharge. Hierarchical Cox hazard regression revealed that patients with unintentional weight loss had a 3.2 times higher risk for cardiac events, adjusting for other clinical factors (P < .001). In hierarchical logistic regression, elevated hsCRP level (odds ratio, 1.49; 95% confidence interval, 1.15-1.92) and depressive symptoms (odds ratio, 1.07, 95% confidence interval, 1.02-1.12) independently predicted unintentional weight loss.

conclusionsUnintentional weight loss was an independent predictor of poor outcomes. Heart failure patients with depressive symptoms and elevated hsCRP levels are at a higher risk for unintentional weight loss.

Indexed as

Weight LossAdultAgedAged, 80 and overC-Reactive ProteinDisease-Free SurvivalFemaleHeart FailureHumansLogistic ModelsMaleMiddle AgedNutritional StatusProspective StudiesC-Reactive Protein

Identifiers

PMID24088622
PMCPMC4130800
OpenAlexW2334620585

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.