ArticleAMB Express2013
Comparing cellular performance of Yarrowia lipolytica during growth on glucose and glycerol in submerged cultivations.
Article in AMB Express, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
45 citing papers in PubMed, 126 citations in OpenAlex.
- Enzyme-constrained genome-scale model of Yarrowia lipolytica predicts growth-phase specific metabolic engineering targets.Applied microbiology and biotechnology · 2026Article
- Article
- Changes in macromolecular content and AOX activity of Ustilago maydis: from exponential to stationary phase.Archives of microbiology · 2025Article
- Substrate-dependent lipid and β-carotene production in engineered Yarrowia lipolytica: a comparative study.AMB Express · 2025Article
- Enhanced low-cost lipopeptide biosurfactant production by Bacillus velezensis from residual glycerin.Bioprocess and biosystems engineering · 2024Article
- Production of perillic acid from orange essential oil by Yarrowia lipolytica using a top-aerated bioreactor.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2023Article
- Efficient production of mycosporine-like amino acids, natural sunscreens, in Yarrowia lipolytica.Biotechnology for biofuels and bioproducts · 2023Article
- Identification and Construction of Strong Promoters inMicroorganisms · 2023Article
- New roles for Yarrowia lipolytica in molecules synthesis and biocontrol.Applied microbiology and biotechnology · 2022Review
- Isopropanol biosynthesis from crude glycerol using fatty acid precursors via engineered oleaginous yeast Yarrowia lipolytica.Microbial cell factories · 2022Article
- Modelling of the Citric Acid Production from Crude Glycerol by Wild-TypeLife (Basel, Switzerland) · 2022Article
- Proteomics Readjustment of theMicroorganisms · 2021Article
- The Role of Hexokinase and Hexose Transporters in Preferential Use of Glucose over Fructose and Downstream Metabolic Pathways in the YeastInternational journal of molecular sciences · 2021Article
- α-Farnesene production from lipid by engineered Yarrowia lipolytica.Bioresources and bioprocessing · 2021Article
- A 37-amino acid loop in the Yarrowia lipolytica hexokinase impacts its activity and affinity and modulates gene expression.Scientific reports · 2021Article
- Application of Random Mutagenesis and Synthetic FadR Promoter forFrontiers in bioengineering and biotechnology · 2021Article
- Analysis ofMetabolic engineering communications · 2020Article
- Synthetic biology, systems biology, and metabolic engineering of Yarrowia lipolytica toward a sustainable biorefinery platform.Journal of industrial microbiology & biotechnology · 2020Review
- Nitrogen as the major factor influencing gene expression inBiotechnology reports (Amsterdam, Netherlands) · 2020Article
- The influence of transketolase on lipid biosynthesis in the yeast Yarrowia lipolytica.Microbial cell factories · 2020Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Yarrowia lipolytica is an attractive host for sustainable bioprocesses due to its ability to utilize a variety of carbon substrates and convert them to a range of different product types (including lipids, organic acids and polyols) under specific conditions. Despite an increasing number of applications for this yeast, relatively few studies have focused on uptake and metabolism of carbon sources, and the metabolic basis for carbon flow to the different products. The focus of this work was quantification of the cellular performance of Y. lipolytica during growth on glycerol, glucose or a mixture of the two. Carbon substrate uptake rate, growth rate, oxygen utilisation (requirement and uptake rate) and polyol yields were estimated in batch cultivations at 1 litre scale. When glucose was used as the sole carbon and energy source, the growth rate was 0.24 h-1 and biomass and CO2 were the only products. Growth on glycerol proceeded at approximately 0.30 h-1, and the substrate uptake rate was 0.02 mol L-1 h-1 regardless of the starting glycerol concentration (10, 20 or 45 g L-1). Utilisation of glycerol was accompanied by higher oxygen uptake rates compared to glucose growth, indicating import of glycerol occurred initially via phosphorylation of glycerol into glycerol-3-phosphate. Based on these results it could be speculated that once oxygen limitation was reached, additional production of NADH created imbalance in the cofactor pools and the polyol formation observed could be a result of cofactor recycling to restore the balance in metabolism.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.