ArticleJournal of the American Chemical Society2013
Direct measurement of the Mn(II) hydration state in metal complexes and metalloproteins through 17O NMR line widths.
Article in Journal of the American Chemical Society, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed.
- Pyridinophane Ligands: An Attractive Chelator Platform for Mn-Based Imaging Agents.Journal of medicinal chemistry · 2026Article
- Manganese-Templated Nontrivial Structures for MRI and Therapy.Journal of the American Chemical Society · 2026Article
- MnChemistry (Weinheim an der Bergstrasse, Germany) · 2025Article
- From electron spin to relaxivity: a multidisciplinary perspective on first-row transition metal-based MRI probes.Chemical science · 2025Review
- Expanding the Family of Monosubstituted 15-Membered Pyridine-Based Macrocyclic Ligands for Mn(II) Complexation in the Context of MRI.Inorganic chemistry · 2025Article
- The Role of Ovalbumin in Manganese Homeostasis during Chick Embryogenesis: An EPR Spectroscopic Study.Molecules (Basel, Switzerland) · 2024Article
- Macrocyclic complexes of Fe(III) with mixed hydroxypropyl and phenolate or amide pendants as TDalton transactions (Cambridge, England : 2003) · 2024Article
- Design and synthesis of chiral DOTA-based MRI contrast agents with remarkable relaxivities.Communications chemistry · 2023Article
- Fe(III)Inorganic chemistry · 2023Article
- Tailored Chemical Reactivity Probes for Systemic Imaging of Aldehydes in Fibroproliferative Diseases.Journal of the American Chemical Society · 2023Article
- A genetically encoded fluorescent sensor for manganese(II), engineered from lanmodulin.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Thermodynamic Stability of Mn(II) Complexes with Aminocarboxylate Ligands Analyzed Using Structural Descriptors.Inorganic chemistry · 2022Article
- Low-Molecular-Weight Fe(III) Complexes for MRI Contrast Agents.Molecules (Basel, Switzerland) · 2022Review
- Metal-Organic Polyhedron with Four Fe(III) Centers Producing Enhanced TInorganic chemistry · 2022Article
- A New Oxygen Containing Pyclen-Type Ligand as a Manganese(II) Binder for MRI andMolecules (Basel, Switzerland) · 2022Article
- Comparison of phosphonate, hydroxypropyl and carboxylate pendants in Fe(III) macrocyclic complexes as MRI contrast agents.Journal of inorganic biochemistry · 2021Article
- Paramagnetic MnACS applied materials & interfaces · 2021Article
- Quinol-containing ligands enable high superoxide dismutase activity by modulating coordination number, charge, oxidation states and stability of manganese complexes throughout redox cycling.Chemical science · 2021Article
- Dinuclear Fe(III) Hydroxypropyl-Appended Macrocyclic Complexes as MRI Probes.Inorganic chemistry · 2021Article
- A Single-Pot Template Reaction Towards a Manganese-Based TAngewandte Chemie (International ed. in English) · 2021Article
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Abstract
Here we describe a simple method to estimate the inner-sphere hydration state of the Mn(II) ion in coordination complexes and metalloproteins. The line width of bulk H2(17)O is measured in the presence and absence of Mn(II) as a function of temperature, and transverse (17)O relaxivities are calculated. It is demonstrated that the maximum (17)O relaxivity is directly proportional to the number of inner-sphere water ligands (q). Using a combination of literature data and experimental data for 12 Mn(II) complexes, we show that this method provides accurate estimates of q with an uncertainty of ±0.2 water molecules. The method can be implemented on commercial NMR spectrometers working at fields of 7 T and higher. The hydration number can be obtained for micromolar Mn(II) concentrations. We show that the technique can be extended to metalloproteins or complex:protein interactions. For example, Mn(II) binds to the multimetal binding site A on human serum albumin with two inner-sphere water ligands that undergo rapid exchange (1.06 × 10(8) s(-1) at 37 °C). The possibility of extending this technique to other metal ions such as Gd(III) is discussed.
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