ArticleAnalytical chemistry2013
New generation of ensemble-decision aliquot ranking based on simplified microfluidic components for large-capacity trapping of circulating tumor cells.
Article in Analytical chemistry, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed.
- Characterization of a Single-Molecule Sensitive Digital Flow Cytometer for Amplification-Free Digital Assays.ACS nano · 2025Article
- Precision Phenotypic Profiling and Capture of Circulating Tumor Cells via a Vertical Laminar Flow-Stacked Microfluidic Chip.Micromachines · 2024Article
- A 3D Capillary-Driven Multi-Micropore Membrane-Based Trigger Valve for Multi-Step Biochemical Reaction.Biosensors · 2022Article
- Isolation of circulating tumor cells.iScience · 2022Review
- Sequential Ensemble-Decision Aliquot Ranking Isolation and FluorescenceAnalytical chemistry · 2021Article
- Incorporation of lateral microfiltration with immunoaffinity for enhancing the capture efficiency of rare cells.Scientific reports · 2020Article
- Isolating Rare Cells and Circulating Tumor Cells with High Purity by Sequential eDAR.Analytical chemistry · 2019Article
- Liquid biopsy in pancreatic ductal adenocarcinoma: current status of circulating tumor cells and circulating tumor DNA.Molecular oncology · 2019Review
- Integrated Microfluidic Device for Enrichment and Identification of Circulating Tumor Cells from the Blood of Patients with Colorectal Cancer.Disease markers · 2019Article
- Optical painting and fluorescence activated sorting of single adherent cells labelled with photoswitchable Pdots.Nature communications · 2016Article
- Development of a 3D printer using scanning projection stereolithography.Scientific reports · 2015Article
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
Ensemble-decision aliquot ranking (eDAR) is a sensitive and high-throughput method to analyze circulating tumor cells (CTCs) from peripheral blood. Here, we report the next generation of eDAR, where we designed and optimized a new hydrodynamic switching scheme for the active sorting step in eDAR, which provided fast cell sorting with an improved reproducibility and stability. The microfluidic chip was also simplified by incorporating a functional area for subsequent purification using microslits fabricated by standard lithography method. Using the reported second generation of eDAR, we were able to analyze 1 mL of whole-blood samples in 12.5 min, with a 95% recovery and a zero false positive rate (n = 15).
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Registered trials
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