ArticlePLoS neglected tropical diseases2013
Microarray analysis of microbiota of gingival lesions in noma patients.
Article in PLoS neglected tropical diseases, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 37 citations in OpenAlex.
- Periodontitis and Periodontal Conditions in Systemically Healthy Children and Adolescents.Journal of clinical periodontology · 2026Review
- Protecting Newborns from Multidrug-Resistant Infections: The Emerging Role of Bacteriophages.Viruses · 2026Review
- Shotgun metagenomic analysis of the oral microbiomes of children with noma.PLoS neglected tropical diseases · 2026Article
- Knowledge, attitudes and practices of healthcare workers towards noma in Zambezia, Mozambique.PLoS neglected tropical diseases · 2025Article
- The key players of dysbiosis in Noma disease; A systematic review of etiological studies.Frontiers in oral health · 2023Review
- Oral Dysbiosis and Neurodegenerative Diseases: Correlations and Potential Causations.Microorganisms · 2022Review
- Noma (cancrum oris): A scoping literature review of a neglected disease (1843 to 2021).PLoS neglected tropical diseases · 2021Article
- Why is noma a neglected-neglected tropical disease?PLoS neglected tropical diseases · 2020Article
- Sociodemographic Characteristics of Traditional Healers and Their Knowledge of Noma: A Descriptive Survey in Three Regions of Mali.International journal of environmental research and public health · 2019Article
- Noma (cancrum oris): An unresolved global challenge.Periodontology 2000 · 2019Review
- Noma: Overview of a Neglected Disease and Human Rights Violation.The American journal of tropical medicine and hygiene · 2017Review
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- A Review on Noma: A Recent Update.Global journal of health science · 2015Review
- Noma affected children from Niger have distinct oral microbial communities based on high-throughput sequencing of 16S rRNA gene fragments.PLoS neglected tropical diseases · 2014Article
- Variation on a theme; an overview of the Tn916/Tn1545 family of mobile genetic elements in the oral and nasopharyngeal streptococci.Frontiers in microbiology · 2014Review
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Noma (cancrum oris) is a gangrenous disease of unknown etiology affecting the maxillo-facial region of young children in extremely limited resource countries. In an attempt to better understand the microbiological events occurring during this disease, we used phylogenetic and low-density microarrays targeting the 16S rRNA gene to characterize the gingival flora of acute noma and acute necrotizing gingivitis (ANG) lesions, and compared them to healthy control subjects of the same geographical and social background. Our observations raise doubts about Fusobacterium necrophorum, a previously suspected causative agent of noma, as this species was not associated with noma lesions. Various oral pathogens were more abundant in noma lesions, notably Atopobium spp., Prevotella intermedia, Peptostreptococcus spp., Streptococcus pyogenes and Streptococcus anginosus. On the other hand, pathogens associated with periodontal diseases such as Aggregatibacter actinomycetemcomitans, Capnocytophaga spp., Porphyromonas spp. and Fusobacteriales were more abundant in healthy controls. Importantly, the overall loss of bacterial diversity observed in noma samples as well as its homology to that of ANG microbiota supports the hypothesis that ANG might be the immediate step preceding noma.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.