ArticlePLoS neglected tropical diseases2013
Association between age and severity to leptospirosis in children.
Article in PLoS neglected tropical diseases, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.
- A systematic review of human and animal leptospirosis in the Pacific Islands reveals pathogen and reservoir diversity.PLoS neglected tropical diseases · 2018Pooled it
- Clinical features and outcomes of neuroleptospirosis in French Guiana: Insights from a retrospective study (2015-2021).PLoS neglected tropical diseases · 2026Article
- Clinical and epidemiological characteristics of leptospirosis in patients under and over 5 years of age in primary health centers in the Peruvian Amazon, 2022-2024.PLoS neglected tropical diseases · 2026Article
- Leptospirosis Incidence Post-Flooding Following Storm Daniel: The First Case Series in Greece.Infectious disease reports · 2024Article
- Identification of Dominant Leptospira Serogroups among Leptospirosis Cases and Their Clinical Outcomes: A Prospective Hospital-Based Study in Mangaluru, India.The American journal of tropical medicine and hygiene · 2024Article
- Pediatric Leptospirosis: A Case Report and Review of Literature.The Eurasian journal of medicine · 2023Article
- Prevalence of Malaria and Leptospirosis Co-Infection among Febrile Patients: A Systematic Review and Meta-Analysis.Tropical medicine and infectious disease · 2021Article
- Application of PCR for Specific Diagnosis of Leptospirosis in Humans in Ukraine.Polish journal of microbiology · 2020Article
- Article
- Childhood leptospirosis in an industrialized country: Population-based study in Okinawa, Japan.PLoS neglected tropical diseases · 2018Article
- The Use of Chemoprophylaxis after Floods to Reduce the Occurrence and Impact of Leptospirosis Outbreaks.International journal of environmental research and public health · 2017Review
- Risk factors for intensive care unit admission in patients with severe leptospirosis: a comparative study according to patients' severity.BMC infectious diseases · 2016Article
- Human leptospirosis: seroreactivity and genetic susceptibility in the population of São Miguel Island (Azores, Portugal).PloS one · 2014Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIn endemic areas, leptospirosis is more common and more severe in adults compared with children. Reasons to explain this discrepancy remain unclear and limited data focusing on adolescents are available. The objective of the study was to describe disease spectrum and outcome differences in children and adolescents admitted for leptospirosis in a large at-risk population.
methodsClinical and laboratory data were obtained on hospitalized cases in New Caledonia from 2006 to 2012.
resultsData of 60 patients <18 years of age (25 children under 14 and 35 adolescents aged 14 to 17) with confirmed leptospirosis were analyzed. Compared with children, adolescents presented more often with classic features of Weil disease (p = 0.02), combining hepatic and renal involvement with or without pulmonary participation. Jarisch-Herxheimer reactions were observed more often among adolescents (p<0.01). The overall case fatality rate was low (1 adolescent versus 0 children).
conclusionSevere leptospirosis in adolescents may be more likely to show adults' characteristics compared with children. Further studies are required to explore age-dependant host factors, including puberty-related physiological changes.
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