Evidence map›Paper›PMID 24086657›Full record

ArticlePloS one2013

Gfi1 and gfi1b repress rag transcription in plasmacytoid dendritic cells in vitro.

Kwan T Chow, Danae Schulz, Sarah M McWhirter, Mark S Schlissel

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Kwan T ChowDepartment of Molecular & Cell Biology, University of California, Berkeley, California, United States of America.
Danae Schulz
Sarah M McWhirter
Mark S Schlissel
University of California, Berkeley · US

Funding

The Regulation of B Lymphocyte DevelopmentR01HL048702 · NHLBI · UNIVERSITY OF CALIFORNIA BERKELEY · PI SCHLISSEL, MARK S. · 1994 to 2011
$4.1M
Biochemistry and Regulation of V(D)J RecombinationR37AI040227 · NIAID · UNIVERSITY OF CALIFORNIA BERKELEY · PI SCHLISSEL, MARK S. · 2005 to 2012
$3.0M
NHLBI NIH HHS R01 HL048702NHLBI NIH HHS R01 HL48702NIAID NIH HHS R37 AI040227NIAID NIH HHS R37 AI40227
6 · The paper itself

Abstract

Growth factor independence genes (Gfi1 and Gfi1b) repress recombination activating genes (Rag) transcription in developing B lymphocytes. Because all blood lineages originate from hematopoietic stem cells (HSCs) and different lineage progenitors have been shown to share transcription factor networks prior to cell fate commitment, we hypothesized that GFI family proteins may also play a role in repressing Rag transcription or a global lymphoid transcriptional program in other blood lineages. We tested the level of Rag transcription in various blood cells when Gfi1 and Gfi1b were deleted, and observed an upregulation of Rag expression in plasmacytoid dendritic cells (pDCs). Using microarray analysis, we observed that Gfi1 and Gfi1b do not regulate a lymphoid or pDC-specific transcriptional program. This study establishes a role for Gfi1 and Gfi1b in Rag regulation in a non-B lineage cell type.

Indexed as

AnimalsComputational BiologyDendritic CellsDNA-Binding ProteinsFlow CytometryGene Expression RegulationHomeodomain ProteinsHumansMiceMicroarray AnalysisProto-Oncogene ProteinsReal-Time Polymerase Chain ReactionRepressor ProteinsReverse Transcriptase Polymerase Chain ReactionTranscription FactorsDNA-Binding ProteinsGfi1b protein, mouseGfi1 protein, mouseHomeodomain ProteinsProto-Oncogene ProteinsRAG-1 proteinRepressor ProteinsTranscription Factors

Identifiers

PMID24086657
PMCPMC3782466
OpenAlexW2033733281

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.