ArticlePloS one2013
Serum estradiol and testosterone levels in kidney stones disease with and without calcium oxalate components in naturally postmenopausal women.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
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Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 38 citations in OpenAlex.
- Univariable and multivariable mendelian randomization study revealed the modifiable risk factors of urolithiasis.PloS one · 2023Pooled it
- Lifestyle factors, serum parameters, metabolic comorbidities, and the risk of kidney stones: a Mendelian randomization study.Frontiers in endocrinology · 2023Pooled it
- Trends and burden of urolithiasis in China, 1990-2021: a systematic analysis of the global burden of disease study 2021 with future projections to 2036.World journal of urology · 2025Article
- Whole Exome Sequencing in Chinese Pediatric Patients With Nephrolithiasis.Kidney international reports · 2025Article
- The influence and relationship of dysbiosis in the urinary microbiota on patients with urolithiasis.Urolithiasis · 2025Article
- Proton pump inhibitors use is associated with a higher prevalence of kidney stones: NHANES 2007-2018.BMC public health · 2024Article
- Review
- The Hidden Link between Polycystic Ovary Syndrome and Kidney Stones: Finding from the Tehran Lipid and Glucose Study (TLGS).Diagnostics (Basel, Switzerland) · 2023Article
- Sex differences in autonomic responses to stress: implications for cardiometabolic physiology.American journal of physiology. Endocrinology and metabolism · 2022Review
- Dietary selenium intake and the risk of kidney stones in adults, an analysis of 2007-2018 National Health and Nutrition Examination Survey, a cross-sectional study.Frontiers in nutrition · 2022Article
- Trends in the prevalence of kidney stones in the United States from 2007 to 2016.Urolithiasis · 2021Article
- Oxalobacter formigenes reduce the risk of kidney stones in patients exposed to oral antibiotics: a case-control study.International urology and nephrology · 2021Article
- Urinary Oxalate Excretion and Long-Term Outcomes in Kidney Transplant Recipients.Journal of clinical medicine · 2019Article
- Postmenopausal hormone and the risk of nephrolithiasis: A meta-analysis.EXCLI journal · 2017Article
- LowCurrent urology · 2015Article
- Clinical Significance of Female-hormones and Cytokines in Breast Cancer Patients Complicated with Aromatase Inhibitor-related Osteoarthropathy - Efficacy of Vitamin E.Journal of Cancer · 2015Article
- Article
- Upper urinary tract stone compositions: the role of age and gender.International braz j urol : official journal of the Brazilian Society of UrologyArticle
- Possible role of elevated serum testosterone in pathogenesis of renal stone formation.International journal of applied & basic medical researchArticle
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveEpidemiological data reveal that the overall risk for kidney stones disease is lower for women compared to age-matched men. However, the beneficial effect for the female sex is lost upon menopause, a time corresponding to the onset of fall in estrogen levels. The aim of this study was to describe the serum estradiol (E2) and testosterone (T) characteristics of naturally postmenopausal women with kidney stones.
methods113 naturally postmenopausal women with newly diagnosed kidney stones (aged 57.4±4.98 years) and 84 age frequency matched stone-free controls (56.9±4.56 years) were validly recruited in the case-control study. The odds ratios (ORs) for the associations between sex hormones and kidney stones were estimated with logistic regression models, adjusting for demographic data and medical history. Patients were also stratified analyzed according to stone components (calcium oxalate stones [COS]; non-calcium oxalate stones [NCOS]).
resultsSerum E2 (21.1 vs. 31.1 pg/ml) was significantly lower in kidney stones patients compared to controls. Post-hoc analysis demonstrated that this effect was driven by COS patients (p<0.001). According to tertiles of the E2 levels, a significant higher frequency of COS was seen in the lowest E2 group (p <0.001). Multiple logistic regression analysis identified E2 level as a strong factor that was independently associated with the risk for COS (per 1 SD increase, OR=0.951, 95% confidence interval [CI] = 0.919-0.985; highest: lowest tertile, OR=0.214, 95%CI = 0.069-0.665). However, serum T levels did not significantly differ among the groups.
conclusionsNaturally postmenopausal women with higher remaining estradiol levels appear less likely to suffer from kidney calcium oxalate stones. However, no correlation was found between serum T level and kidney stones. These findings support the hypothesis that higher postmenopausal endogenous estrogens may protect against kidney stones with ageing.
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