ArticlePloS one2013
Prevalence of dural ectasia in Loeys-Dietz syndrome: comparison with Marfan syndrome and normal controls.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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14 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.
- Neurovascular complications in Loeys-Dietz syndrome: a comprehensive systematic review and case report.Acta neurologica Belgica · 2026Pooled it
- Hirayama Disease in A Patient with Loeys-Dietz Syndrome: The First Reported Association.European journal of case reports in internal medicine · 2026Article
- New CT-based dural ectasia criteria using machine learning to diagnose Marfan and Loeys-Dietz syndromes.European heart journal. Imaging methods and practice · 2026Article
- Management of Tarlov cysts: an uncommon but potentially serious spinal column disease-review of the literature and experience with over 1000 referrals.Neuroradiology · 2024Review
- The Musculoskeletal Manifestations of Marfan Syndrome: Diagnosis, Impact, and Management.Current rheumatology reports · 2021Review
- Physiological pseudo-thickened cauda equina associated with dural sac dilatation on magnetic resonance imaging.The neuroradiology journal · 2021Article
- Spontaneous intracranial hypotension secondary to congenital spinal dural ectasia and genetic mosaicism for tetrasomy 10p: illustrative case.Journal of neurosurgery. Case lessons · 2021Article
- Loeys-Dietz syndrome in pregnancy.Obstetric medicine · 2021Article
- Lady Windermere Dissected: More Form Than Fastidious.Annals of the American Thoracic Society · 2016Article
- Enlarged Dural Sac in Idiopathic Bronchiectasis Implicates Heritable Connective Tissue Gene Variants.Annals of the American Thoracic Society · 2016Article
- Marfan syndrome: current perspectives.The application of clinical genetics · 2016Review
- Standardization and validation of a novel and simple method to assess lumbar dural sac size.Clinical radiology · 2015Article
- Further delineation of Loeys-Dietz syndrome type 4 in a family with mild vascular involvement and a TGFB2 splicing mutation.BMC medical genetics · 2014Article
- Marsupialization and distal obliteration of a lumbosacral dural ectasia in a nonsyndromic, adult patient.Journal of craniovertebral junction & spineArticle
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposeDural ectasia is well recognized in Marfan syndrome (MFS) as one of the major diagnostic criteria, but the exact prevalence of dural ectasia is still unknown in Loeys-Dietz syndrome (LDS), which is a recently discovered connective tissue disease. In this study, we evaluated the prevalence of dural ectasia in LDS according by using qualitative and quantitative methods and compared our findings with those for with MFS and normal controls. MATERIAL AND
methodsWe retrospectively studied 10 LDS (6 males, 4 females, mean age 36.3 years) and 20 MFS cases (12 males, 8 females, mean age 37.1 years) and 20 controls (12 males, 8 females, mean age 36.1 years) both qualitatively and quantitatively using axial CT images and sagittal multi-planar reconstruction images of the lumbosacral region. For quantitative examination, we adopted two methods: method-1 (anteroposterior dural diameter of S1> L4) and method-2 (ratio of anteroposterior dural diameter/vertebral body diameter>cutoff values). The prevalence of dural ectasia among groups was compared by using Fisher's exact test and the Tukey-Kramer test.
resultsIn LDS patients, the qualitative method showed 40% of dural ectasia, the quantitative method-1 50%, and the method-2 70%. In MFS patients, the corresponding prevalences were 50%, 75%, and 85%, and in controls, 0%, 0%, and 5%. Both LDS and MFS had a significantly wider dura than controls.
conclusionsWhile the prevalence of dural ectasia varied depending on differences in qualitative and quantitative methods, LDS as well as MFS, showed, regardless of method, a higher prevalence of dural ectasia than controls. This finding should help the differentiation of LDS from controls.
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