ArticlePloS one2013
Ultrastructural abnormalities in CA1 hippocampus caused by deletion of the actin regulator WAVE-1.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- A PDZ-RapGEF promotes synaptic development in Caenorhabditis elegans through a Rap/Rac signaling pathway.Development (Cambridge, England) · 2025Article
- Orchestration of synaptic functions by WAVE regulatory complex-mediated actin reorganization.Experimental & molecular medicine · 2023Review
- RGMa and Neogenin control dendritic spine morphogenesis via WAVE Regulatory Complex-mediated actin remodeling.Frontiers in molecular neuroscience · 2023Article
- WAVE1 and WAVE2 have distinct and overlapping roles in controlling actin assembly at the leading edge.Molecular biology of the cell · 2020Article
- The role of PHOX2B-derived astrocytes in chemosensory control of breathing and sleep homeostasis.The Journal of physiology · 2019Article
- CCNA2 Ablation in Aged Mice Results in Abnormal rRNA Granule Accumulation in Hippocampus.The American journal of pathology · 2019Article
- Myosin XVI Regulates Actin Cytoskeleton Dynamics in Dendritic Spines of Purkinje Cells and Affects Presynaptic Organization.Frontiers in cellular neuroscience · 2019Article
- Quantitative Electron Microscopic Assay Using Random Sampling from Single Sections to Test Plastic Synaptic Changes in Hippocampus.Bio-protocol · 2018Article
- De Novo Truncating Mutations in WASF1 Cause Intellectual Disability with Seizures.American journal of human genetics · 2018Article
- New insights into the regulatory function of CYFIP1 in the context of WAVE- and FMRP-containing complexes.Disease models & mechanisms · 2017Article
- Parental origin impairment of synaptic functions and behaviors in cytoplasmic FMRP interacting protein 1 (Cyfip1) deficient mice.Brain research · 2015Article
- Actin Out: Regulation of the Synaptic Cytoskeleton.The Journal of biological chemistry · 2015Review
- Protein kinase D promotes plasticity-induced F-actin stabilization in dendritic spines and regulates memory formation.The Journal of cell biology · 2015Article
- A novel role for WAVE1 in controlling actin network growth rate and architecture.Molecular biology of the cell · 2015Article
- CYFIP family proteins between autism and intellectual disability: links with Fragile X syndrome.Frontiers in cellular neuroscience · 2014Review
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
By conveying signals from the small GTPase family of proteins to the Arp2/3 complex, proteins of the WAVE family facilitate actin remodeling. The WAVE-1 isoform is expressed at high levels in brain, where it plays a role in normal synaptic processing, and is implicated in hippocampus-dependent memory retention. We used electron microscopy to determine whether synaptic structure is modified in the hippocampus of WAVE-1 knockout mice, focusing on the neuropil of CA1 stratum radiatum. Mice lacking WAVE-1 exhibited alterations in the morphology of both axon terminals and dendritic spines; the relationship between the synaptic partners was also modified. The abnormal synaptic morphology we observed suggests that signaling through WAVE-1 plays a critical role in establishing normal synaptic architecture in the rodent hippocampus.
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Registered trials
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