ArticlePloS one2013
Asymmetric migration of human keratinocytes under mechanical stretch and cocultured fibroblasts in a wound repair model.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 38 citations in OpenAlex.
- The Multifaceted Role of Keratinocytes in Hidradenitis Suppurativa Pathogenesis.Experimental dermatology · 2026Review
- Matrix Stiffness Modulates Fibroblast Paracrine Signaling to Enhance Autophagy in Keratinocytes: Implications for Wound Healing.ACS omega · 2026Article
- Advances in Microengineered Platforms for Skin Research.JID innovations : skin science from molecules to population health · 2025Review
- Effect of placental mesenchymal stem cells on promoting the healing of chronic burn wounds.Heliyon · 2024Article
- Liquid plasma as a treatment for cutaneous wound healing through regulation of redox metabolism.Cell death & disease · 2023Article
- Skin-on-a-Chip Technology: Microengineering Physiologically Relevant In Vitro Skin Models.Pharmaceutics · 2022Review
- The Epidermis in Microgravity and Unloading Conditions and Their Effects on Wound Healing.Frontiers in bioengineering and biotechnology · 2022Review
- A Hierarchy of Proliferative and Migratory Keratinocytes Maintains the Tympanic Membrane.Cell stem cell · 2021Article
- Botrops derived hemocoagulase formulation a probable agent for diabetic wound healing.3 Biotech · 2020Article
- Developmental aspects of the tympanic membrane: Shedding light on function and disease.Genesis (New York, N.Y. : 2000) · 2020Review
- Mechanical stretch induces hair regeneration through the alternative activation of macrophages.Nature communications · 2019Article
- Effect of Mechanical Stretch on the DNCB-induced Proinflammatory Cytokine Secretion in Human Keratinocytes.Scientific reports · 2019Article
- Computational model of wound healing: EGF secreted by fibroblasts promotes delayed re-epithelialization of epithelial keratinocytes.Integrative biology : quantitative biosciences from nano to macro · 2018Article
- Preferential sensing and response to microenvironment stiffness of human dermal fibroblast cultured on protein micropatterns fabricated by 3D multiphoton biofabrication.Scientific reports · 2017Article
- Simulated microgravity triggers epithelial mesenchymal transition in human keratinocytes.Scientific reports · 2017Article
- Bridging the gap: microfluidic devices for short and long distance cell-cell communication.Lab on a chip · 2017Review
- Modeling, signaling and cytoskeleton dynamics: integrated modeling-experimental frameworks in cell migration.Wiley interdisciplinary reviews. Systems biology and medicine · 2017Review
- β1 integrin signaling in asymmetric migration of keratinocytes under mechanical stretch in a co-cultured wound repair model.Biomedical engineering online · 2016Article
- Effects of mechanical stretching on the morphology and cytoskeleton of vaginal fibroblasts from women with pelvic organ prolapse.International journal of molecular sciences · 2015Article
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Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Keratinocyte migration during re-epithelization is crucial in wound healing under biochemical and biomechanical microenvironment. However, little is known about the underlying mechanisms whereby mechanical tension and cocultured fibroblasts or keratinocytes modulate the migration of keratinocytes or fibroblasts. Here we applied a tensile device together with a modified transwell assay to determine the lateral and transmembrane migration dynamics of human HaCaT keratinocytes or HF fibroblasts. A novel pattern of asymmetric migration was observed for keratinocytes when they were cocultured with non-contact fibroblasts, i.e., the accumulative distance of HaCaT cells was significantly higher when moving away from HF cells or migrating from down to up cross the membrane than that when moving close to HF cells or when migrating from up to down, whereas HF migration was symmetric. This asymmetric migration was mainly regulated by EGF derived from fibroblasts, but not transforming growth factor α or β1 production. Mechanical stretch subjected to fibroblasts fostered keratinocyte asymmetric migration by increasing EGF secretion, while no role of mechanical stretch was found for EGF secretion by keratinocytes. These results provided a new insight into understanding the regulating mechanisms of two- or three-dimensional migration of keratinocytes or fibroblasts along or across dermis and epidermis under biomechanical microenvironment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.