ArticlePloS one2013
A conserved virulence plasmidic region contributes to the virulence of the multiresistant Escherichia coli meningitis strain S286 belonging to phylogenetic group C.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.
- Global Extraintestinal Pathogenic Escherichia coli (ExPEC) Lineages.Clinical microbiology reviews · 2019Pooled it
- Integrating Diagnostic Approaches in Infant Bacterial Meningitis Caused by a Non-K1Antibiotics (Basel, Switzerland) · 2024Article
- Pathogenome comparison and global phylogeny of Escherichia coli ST1485 strains.Scientific reports · 2022Article
- Recurrent bacteremia with a hypermucoviscous Escherichia coli isolated from a patient with perihilar cholangiocarcinoma: insights from a comprehensive genome-based analysis.Annals of clinical microbiology and antimicrobials · 2022Article
- A role for ColV plasmids in the evolution of pathogenic Escherichia coli ST58.Nature communications · 2022Article
- Impact ofVeterinary and animal science · 2021Article
- Role of Plasmids in the Ecology and Evolution of "High-Risk" Extraintestinal PathogenicEcoSal Plus · 2021Review
- The population genetics of pathogenic Escherichia coli.Nature reviews. Microbiology · 2021Review
- Extended Phylogeny and Extraintestinal Virulence Potential of CommensalInternational journal of environmental research and public health · 2020Article
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- Comparison of Commensal Escherichia coli Isolates from Adults and Young Children in Lubuskie Province, Poland: Virulence Potential, Phylogeny and Antimicrobial Resistance.International journal of environmental research and public health · 2018Article
- Spondylodiscitis in a healthy 12-year-old girl with Extraintestinal pathogenic Escherichia coli (ExPEC) bacteraemia.BMC infectious diseases · 2017Article
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- Fatal necrotizing fasciitis due to necrotic toxin-producing Escherichia coli strain.New microbes and new infections · 2015Article
- Genomic characterisation of an endometrial pathogenic Escherichia coli strain reveals the acquisition of genetic elements associated with extra-intestinal pathogenicity.BMC genomics · 2014Article
- Group A Escherichia coli-related purpura fulminans: an unusual manifestation due to an unusual strain?Journal of clinical microbiology · 2014Article
- First identification of a chromosomally located penicillinase gene in Kingella kingae species isolated in continental Europe.Antimicrobial agents and chemotherapy · 2014Article
- Haemolytic-uraemic syndrome with bacteraemia caused by a new hybrid Escherichia coli pathotype.New microbes and new infections · 2014Article
- Molecular screening of virulence genes in extraintestinal pathogenic Escherichia coli isolated from human blood culture in Brazil.BioMed research international · 2014Article
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent isolation of the non-K1 Escherichia coli neonatal meningitis strain S286, belonging to phylogroup C, which is closely related to major group B1, and producing an extended-spectrum beta-lactamase, encouraged us to seek the genetic determinants responsible for its virulence. We show that S286 belongs to the sequence O type ST23O78 and harbors 4 large plasmids. The largest one, pS286colV (~120 kb), not related to resistance, contains genes characteristic of a Conserved Virulence Plasmidic (CVP) region initially identified in B2 extra-intestinal avian pathogenic E. coli (APEC) strains and in the B2 neonatal meningitis E. coli strain S88. The sequence of this CVP region has a strong homology (98%) with that of the recently sequenced plasmid pChi7122-1 of the O78 APEC strain Chi7122. A CVP plasmid-cured variant of S286 was less virulent than the wild type strain in a neonatal rat sepsis model with a significant lower level of bacteremia at 24 h (4.1 ± 1.41 versus 2.60 ± 0.16 log CFU/ml, p = 0.001) and mortality. However, the mortality in the model of adult mice was comparable between wild type and variant indicating that pS286colV is not sufficient by itself to fully explain the virulence of S286. Gene expression analysis of pS286colV in iron depleted environment was very close to that of pS88, suggesting that genes of CVP region may be expressed similarly in two very different genetic backgrounds (group C versus group B2). Screening a collection of 178 human A/B1 extraintestinal pathogenic E. coli (ExPEC) strains revealed that the CVP region is highly prevalent (23%) and MLST analysis indicated that these CVP positive strains belong to several clusters and mostly to phylogroup C. The virulence of S286 is explained in part by the presence of CVP region and this region has spread in different clusters of human A/B1 ExPEC, especially in group C.
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