ArticlePloS one2013
Plasma proteome profiles associated with diet-induced metabolic syndrome and the early onset of metabolic syndrome in a pig model.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Mediterranean diet impact on plasma proteins: biomarker networks linking nutrition to the modulation of inflammation and oxidative stress.Frontiers in nutrition · 2026Review
- Protocol for in vivo assessment of glucose control and insulin secretion and sensitivity in the pig.STAR protocols · 2025Article
- Sustained Release of Salicylic Acid for Halting Peri-Implantitis Progression in Healthy and Hyperglycemic Systemic Conditions: A Gottingen Minipig Model.ACS biomaterials science & engineering · 2024Article
- Osseointegration of implant surfaces in metabolic syndrome and type-2 diabetes mellitus.Journal of biomedical materials research. Part B, Applied biomaterials · 2024Article
- Bone healing around implants placed in subjects with metabolically compromised systemic conditions.Journal of biomedical materials research. Part B, Applied biomaterials · 2023Article
- Plasma protein levels of young healthy pigs as indicators of disease resilience.Journal of animal science · 2023Article
- Hepatic galectin-3 is associated with lipid droplet area in non-alcoholic steatohepatitis in a new swine model.Scientific reports · 2022Article
- Extensive heterogeneity of glycopeptides in plasma revealed by deep glycoproteomic analysis using size-exclusion chromatography.Molecular omics · 2021Article
- Analysis of merged whole blood transcriptomic datasets to identify circulating molecular biomarkers of feed efficiency in growing pigs.BMC genomics · 2021Article
- Article
- Toward a porcineGut microbes · 2020Article
- Regulating appetite in broilers for improving body and muscle development - A review.Journal of animal physiology and animal nutrition · 2020Review
- Prevention of Early Alzheimer's Disease by Erinacine A-EnrichedFrontiers in aging neuroscience · 2020Article
- Sanitary Conditions Affect the Colonic Microbiome and the Colonic and Systemic Metabolome of Female Pigs.Frontiers in veterinary science · 2020Article
- Changes in Plasma Protein Expression Indicative of Early Diet-induced Metabolic Disease in Male Pigs (Comparative medicine · 2018Article
- Effect of Obesity or Metabolic Syndrome and Diabetes on Osseointegration of Dental Implants in a Miniature Swine Model: A Pilot Study.Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons · 2018Article
- Strategies towards Improved Feed Efficiency in Pigs Comprise Molecular Shifts in Hepatic Lipid and Carbohydrate Metabolism.International journal of molecular sciences · 2017Article
- Investigating the Metabolic Syndrome: Contributions of Swine Models.Toxicologic pathology · 2016Review
- NMR-based metabolomics highlights differences in plasma metabolites in pigs exhibiting diet-induced differences in adiposity.European journal of nutrition · 2016Article
- High-fat diet combined with low-dose streptozotocin injections induces metabolic syndrome in Macaca mulatta.Endocrine · 2015Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Obesity and related diabetes are important health threatening multifactorial metabolic diseases and it has been suggested that 25% of all diabetic patients are unaware of their patho-physiological condition. Biomarkers for monitoring and control are available, but early stage predictive biomarkers enabling prevention of these diseases are still lacking. We used the pig as a model to study metabolic disease because humans and pigs share a multitude of metabolic similarities. Diabetes was chemically induced and control and diabetic pigs were either fed a high unsaturated fat (Mediterranean) diet or a high saturated fat/cholesterol/sugar (cafeteria) diet. Physiological parameters related to fat metabolism and diabetes were measured. Diabetic pigs' plasma proteome profiles differed more between the two diets than control pigs plasma proteome profiles. The expression levels of several proteins correlated well with (patho)physiological parameters related to the fat metabolism (cholesterol, VLDL, LDL, NEFA) and diabetes (Glucose) and to the diet fed to the animals. Studying only the control pigs as a model for metabolic syndrome when fed the two diets showed correlations to the same parameters but now more focused on insulin, glucose and abdominal fat depot parameters. We conclude that proteomic profiles can be used as a biomarker to identify pigs with developing metabolic syndrome (prediabetes) and diabetes when fed a cafeteria diet. It could be developed into a potential biomarkers for the early recognition of metabolic diseases.
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