Trial reportPloS one2013
HIV-1 transmission during early antiretroviral therapy: evaluation of two HIV-1 transmission events in the HPTN 052 prevention study.
Trial report in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Risk of sexual transmission of human immunodeficiency virus with antiretroviral therapy, suppressed viral load and condom use: a systematic review.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2018Pooled it
- Virologic outcomes in early antiretroviral treatment: HPTN 052.HIV clinical trials · 2017Trial
- Treatment as Prevention: Characterization of Partner Infections in the HIV Prevention Trials Network 052 Trial.Journal of acquired immune deficiency syndromes (1999) · 2017Trial
- Antiretroviral Therapy for the Prevention of HIV-1 Transmission.The New England journal of medicine · 2016Trial
- Diminished social support as an explanatory mechanism in the relationship between stigma and engagement HIV care.Journal of behavioral medicine · 2025Article
- Qualitative analysis of HIV and AIDS disease transmission: impact of awareness, testing and effective follow up.F1000Research · 2022Article
- Mathematical modeling of HIV-HCV co-infection model: Impact of parameters on reproduction number.F1000Research · 2022Article
- Addressing Ethical Challenges in US-Based HIV Phylogenetic Research.The Journal of infectious diseases · 2020Article
- Article
- Safer conception among HIV-1 serodiscordant couples in East Africa: understanding knowledge, attitudes, and experiences.AIDS care · 2018Article
- Deciphering Multiplicity of HIV-1C Infection: Transmission of Closely Related Multiple Viral Lineages.PloS one · 2016Article
- Pharmacokinetic Modeling of Lamivudine and Zidovudine Triphosphates Predicts Differential Pharmacokinetics in Seminal Mononuclear Cells and Peripheral Blood Mononuclear Cells.Antimicrobial agents and chemotherapy · 2015Article
- Previously undiagnosed HIV infections identified through cluster investigation, North Carolina, 2002-2007.AIDS and behavior · 2015Article
- Biomedical prevention: state of the science.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
In the HPTN 052 study, transmission between HIV-discordant couples was reduced by 96% when the HIV-infected partner received suppressive antiretroviral therapy (ART). We examined two transmission events where the newly infected partner was diagnosed after the HIV-infected partner (index) initiated therapy. We evaluated the sequence complexity of the viral populations and antibody reactivity in the newly infected partner to estimate the dates of transmission to the newly infected partners. In both cases, transmission most likely occurred significantly before HIV-1 diagnosis of the newly infected partner, and either just before the initiation of therapy or before viral replication was adequately suppressed by therapy of the index. This study further strengthens the conclusion about the efficacy of blocking transmission by treating the infected partner of discordant couples. However, this study does not rule out the potential for HIV-1 transmission to occur shortly after initiation of ART, and this should be recognized when antiretroviral therapy is used for HIV-1 prevention.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.