ArticlePloS one2013
Characterization of the gut-associated microbiome in inflammatory pouch complications following ileal pouch-anal anastomosis.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 1 of them a synthesis that pooled it.
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Who cites it
50 citing papers in PubMed, 1 synthesis or guideline pooled it, 95 citations in OpenAlex.
- Relationship between pouch microbiota and pouchitis following restorative proctocolectomy for ulcerative colitis.World journal of gastroenterology · 2014Pooled it
- The Gut Microbiome in Pouchitis: A Narrative Review of Pathogenesis and Therapeutic Modulation.Nutrients · 2026Review
- Crohn's-like Ileal Pouch Illness and Ileal Pouch Salvage Strategies.Clinics in colon and rectal surgery · 2025Review
- Role of Probiotics in the Management of Patients with Ulcerative Colitis and Pouchitis.Microorganisms · 2024Review
- Article
- Ileal Paneth Cell Phenotype is a Cellular Biomarker for Pouch Complications in Ulcerative Colitis.Journal of Crohn's & colitis · 2024Article
- Analyzing lung cancer risks in patients with impaired pulmonary function through characterization of gut microbiome and metabolites.BMC pulmonary medicine · 2024Article
- Characteristics of the gut microbiota and serum metabolites in postmenopausal women with reduced bone mineral density.Frontiers in cellular and infection microbiology · 2024Article
- The Effects of Temperature and Humidity Index on Growth Performance, Colon Microbiota, and Serum Metabolome of Ira Rabbits.Animals : an open access journal from MDPI · 2023Article
- Prevalence of Clostridioides difficile Infection After Ileal Pouch-anal Anastomosis in Patients With Chronic Antibiotic-dependent Pouchitis and Crohn's-like Disease of the Pouch.Inflammatory bowel diseases · 2023Article
- Fecal and Tissue Microbiota Are Associated with Tumor T-Cell Infiltration and Mesenteric Lymph Node Involvement in Colorectal Cancer.Nutrients · 2023Article
- Association between lignan polyphenol bioavailability and enterotypes of isoflavone metabolism: A cross-sectional analysis.PloS one · 2023Article
- Early Pouchitis Is Associated With Crohn's Disease-like Pouch Inflammation in Patients With Ulcerative Colitis.Inflammatory bowel diseases · 2022Article
- Ileal Pouch-Anal Anastomosis and Pouchitis: The Role of the Microbiota in the Pathogenesis and Therapy.Nutrients · 2022Review
- Characteristics of the Intestinal Microorganisms in Middle-Aged and Elderly Patients: Effects of Smoking.ACS omega · 2022Article
- Pouchitis: insight into the pathogenesis and clinical aspects.American journal of translational research · 2022Review
- Medical management of chronic pouch inflammation.Current research in pharmacology and drug discovery · 2022Review
- Article
- Immunoglobulin subtype-coated bacteria are correlated with the disease activity of inflammatory bowel disease.Scientific reports · 2021Article
- A Comprehensive Assessment of the Safety ofMicroorganisms · 2021Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionInflammatory complications following ileal pouch-anal anastomosis (IPAA) for ulcerative colitis (UC) are common and thought to arise through mechanisms similar to de novo onset inflammatory bowel disease. The aim of this study was to determine whether specific organisms in the tissue-associated microbiota are associated with inflammatory pouch complications.
methodsPatients having previously undergone IPAA were recruited from Mount Sinai Hospital. Clinical and demographic information were collected and a pouchoscopy with biopsy of both the pouch and afferent limb was performed. Patients were classified based on post-surgical phenotype into four outcome groups: familial adenomatous polyposis controls (FAP), no pouchitis, pouchitis, and Crohn's disease-like (CDL). Pyrosequencing of the 16S rRNA V1-V3 hypervariable region, and quantitative PCR for bacteria of interest, were used to identify organisms present in the afferent limb and pouch. Associations with outcomes were evaluated using exact and non-parametric tests of significance.
resultsAnalysis at the phylum level indicated that Bacteroidetes were detected significantly less frequently (P<0.0001) in the inflammatory outcome groups (pouchitis and CDL) compared to both FAP and no pouchitis. Conversely, Proteobacteria were detected more frequently in the inflammatory groups (P=0.01). At the genus level, organisms associated with outcome were detected less frequently among the inflammatory groups compared to those without inflammation. Several of these organisms, including Bacteroides (P<0.0001), Parabacteroides (P≤2.2x10(-3)), Blautia (P≤3.0x10(-3)) and Sutterella (P≤2.5x10(-3)), were associated with outcome in both the pouch and afferent limb. These associations remained significant even following adjustment for antibiotic use, smoking, country of birth and gender. Individuals with quiescent disease receiving antibiotic therapy displayed similar reductions in these organisms as those with active pouch inflammation.
conclusionsSpecific genera are associated with inflammation of the ileal pouch, with a reduction of typically ubiquitous organisms characterizing the inflammatory phenotypes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.