Evidence map›Paper›PMID 24086042›Full record

ReviewCold Spring Harbor perspectives in biology2013

Nucleotide excision repair in eukaryotes.

Orlando D Schärer

Open access · greenAbstract readReview
In one paragraph

Review in Cold Spring Harbor perspectives in biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 471 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
471citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

471 citing papers in PubMed, 1 synthesis or guideline pooled it, 781 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Review
  5. Review
  6. Review
  7. Review
  8. Host DNA repair factors empower a mechanism of antiviral nucleoside analog resistance.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  9. Article
  10. Article
  11. Review
  12. Somatic mutations and genome mosaicism in aging and disease.Experimental & molecular medicine · 2026
    Review
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Review

411 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Orlando D SchärerDepartment of Pharmacological Sciences and Department of Chemistry, Stony Brook University, Stony Brook, New York 11974-3400.
Stony Brook University · US

Funding

Transcription-Coupled & Replication-Associated Excision RepairP01CA092584 · NCI · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI John A. Tainer · 2001 to 2026
$89.6M
Coordination of the late steps of human nucleotide excision repairR01GM080454 · NIGMS · STATE UNIVERSITY NEW YORK STONY BROOK · PI SCHARER, ORLANDO D. · 2007 to 2010
$1.4M
NCI NIH HHS CA092854NCI NIH HHS P01 CA092584NIGMS NIH HHS GM080454NIGMS NIH HHS R01 GM080454
6 · The paper itself

Abstract

Nucleotide excision repair (NER) is the main pathway used by mammals to remove bulky DNA lesions such as those formed by UV light, environmental mutagens, and some cancer chemotherapeutic adducts from DNA. Deficiencies in NER are associated with the extremely skin cancer-prone inherited disorder xeroderma pigmentosum. Although the core NER reaction and the factors that execute it have been known for some years, recent studies have led to a much more detailed understanding of the NER mechanism, how NER operates in the context of chromatin, and how it is connected to other cellular processes such as DNA damage signaling and transcription. This review emphasizes biochemical, structural, cell biological, and genetic studies since 2005 that have shed light on many aspects of the NER pathway.

Indexed as

DNA DamageDNA RepairAnimalsChromatinChromatin Assembly and DisassemblyDNAEukaryotaHumansModels, GeneticModels, MolecularSubstrate SpecificityChromatinDNA

Identifiers

PMID24086042
PMCPMC3783044
OpenAlexW2097124161

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.