ArticleProceedings of the National Academy of Sciences of the United States of America2013
Insights into insect wing origin provided by functional analysis of vestigial in the red flour beetle, Tribolium castaneum.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
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49 citing papers in PubMed, 119 citations in OpenAlex.
- Non-Invaginated Wing Primordia in Holometabolous Insects: First Report From Mecoptera.Evolution & development · 2026Article
- Deep learning and attention mechanisms to identify key genes and their implications for the origin of insect wings.Scientific reports · 2026Article
- Comparative Analysis of Transcriptome Data of Wings from Different Developmental Stages of theInternational journal of molecular sciences · 2025Article
- WingAnalogy: a computer vision-based tool for automated insect wing asymmetry and morphometry analysis.Scientific reports · 2024Article
- Insect Flight: State of the Field and Future Directions.Integrative and comparative biology · 2024Article
- A new suite of reporter vectors and a novel landing site survey system to study cis-regulatory elements in diverse insect species.Scientific reports · 2024Article
- A cis-regulatory sequence of the selector gene vestigial drives the evolution of wing scaling in Drosophila species.The Journal of experimental biology · 2023Article
- Transcriptomic exploration of the Coleopteran wings reveals insight into the evolution of novel structures associated with the beetle elytron.Journal of experimental zoology. Part B, Molecular and developmental evolution · 2023Article
- Beetle elytra: evolution, modifications and biological functions.Biology letters · 2023Review
- Mitochondria dysfunction impairs Tribolium castaneum wing development during metamorphosis.Communications biology · 2022Article
- Review
- A hemimetabolous wing development suggests the wing origin from lateral tergum of a wingless ancestor.Nature communications · 2022Article
- ThemicroPublication biology · 2022Article
- Out from under the wing: reconceptualizing the insect wing gene regulatory network as a versatile, general module for body-wall lobes in arthropods.Proceedings. Biological sciences · 2021Article
- Transcriptome dynamics during metamorphosis of imaginal discs into wings and thoracic dorsum in Apis mellifera castes.BMC genomics · 2021Article
- Wing serial homologues and the diversification of insect outgrowths: insights from the pupae of scarab beetles.Proceedings. Biological sciences · 2021Article
- Two sets of candidate crustacean wing homologues and their implication for the origin of insect wings.Nature ecology & evolution · 2020Article
- Knockout of crustacean leg patterning genes suggests that insect wings and body walls evolved from ancient leg segments.Nature ecology & evolution · 2020Article
- Tissue-specific developmental regulation and isoform usage underlie the role ofRoyal Society open science · 2020Article
- Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Despite accumulating efforts to unveil the origin of insect wings, it remains one of the principal mysteries in evolution. Currently, there are two prominent models regarding insect wing origin: one connecting the origin to the paranotal lobe and the other to the proximodorsal leg branch (exite). However, neither hypothesis has been able to surpass the other. To approach this conundrum, we focused our analysis on vestigial (vg), a critical wing gene initially identified in Drosophila. Our investigation in Tribolium (Coleoptera) has revealed that, despite the well-accepted view of vg as an essential wing gene, there are two groups of vg-dependent tissues in the "wingless" first thoracic segment (T1). We show that one of these tissues, the carinated margin, also depends on other factors essential for wing development (such as Wingless signal and apterous), and has nubbin enhancer activity. In addition, our homeotic mutant analysis shows that wing transformation in T1 originates from both the carinated margin and the other vg-dependent tissue, the pleural structures (trochantin and epimeron). Intriguingly, these two tissues may actually be homologous to the two proposed wing origins (paranotal lobes and exite bearing proximal leg segments). Therefore, our findings suggest that the vg-dependent tissues in T1 could be wing serial homologs present in a more ancestral state, thus providing compelling functional evidence for the dual origin of insect wings.
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