Evidence map›Paper›PMID 24085737›Full record

SynthesisThe British journal of psychiatry : the journal of mental science2013

Treatment for mild cognitive impairment: systematic review.

Claudia Cooper, Ryan Li, Constantine Lyketsos, Gill Livingston

Erratum issued Registry-linked trialOpen access · bronzeAbstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in The British journal of psychiatry : the journal of mental science, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT05602467 (Efficacy of a 24-week Long Term Transcranial Pulse Stimulation), which is not on this map. Cited by 93 papers, 17 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
93citing papers in PubMed, 17 pooled it
11.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05602467 naunknown statusnot on this mapstarted 2022, after this paper: background citation

Efficacy of a 24-week Long Term Transcranial Pulse Stimulation (TPS) on Cognition and Brain Structure in Older Adults With Mild Neurocognitive Disorder (NCD)

TypeinterventionalSponsorThe University of Hong KongRan2022 to 2024Enrolled22ConditionsMild Neurocognitive DisorderArmsTranscranial Pulse Stimulation (TPS), Treatment as usual (TAU)
3 · Its place in the literature

Who cites it

93 citing papers in PubMed, 17 syntheses or guidelines pooled it, 227 citations in OpenAlex.

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  19. Effects on cognition of 20-day anodal transcranial direct current stimulation over the left dorsolateral prefrontal cortex in patients affected by mild cognitive impairment: a case-control study.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2019
    Trial
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33 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 3 countries.

Claudia CooperClaudia Cooper, MRCPsych, PhD, Ryan Li, BSc, Mental Health Sciences Unit, University College London, UK; Constantine Lyketsos, MD, MHS, Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine and Johns Hopkins Bayview, Johns Hopkins Medicine, Baltimore, Maryland, USA; Gill Livingston, FRCPsych, MD, Mental Health Sciences Unit, University College London, UK.
Ryan Li
Constantine Lyketsos
Gill Livingston
Johns Hopkins University · USUCL Australia · AUUniversity College London · GB

Funding

'T V ASSESSMENT - MEMORY DISORDERED PATIENTS'P50AG005146 · NIA · JOHNS HOPKINS UNIVERSITY · PI ALBERT, MARILYN S. · 1985 to 2019
$37.6M
NIA NIH HHS P50 AG005146
6 · The paper itself

Abstract

backgroundMore people are presenting with mild cognitive impairment (MCI), frequently a precursor to dementia, but we do not know how to reduce deterioration.

aimsTo systematically review randomised controlled trials (RCTs) evaluating the effects of any intervention for MCI on cognitive, neuropsychiatric, functional, global outcomes, life quality or incident dementia.

methodWe reviewed 41 studies fitting predetermined criteria, assessed validity using a checklist, calculated standardised outcomes and prioritised primary outcome findings in placebo-controlled studies.

resultsThe strongest evidence was that cholinesterase inhibitors did not reduce incident dementia. Cognition improved in single trials of: a heterogeneous psychological group intervention over 6 months; piribedil, a dopamine agonist over 3 months; and donepezil over 48 weeks. Nicotine improved attention over 6 months. There was equivocal evidence that Huannao Yicong improved cognition and social functioning.

conclusionsThere was no replicated evidence that any intervention was effective. Cholinesterase inhibitors and rofecoxib are ineffective in preventing dementia. Further good-quality RCTs are needed and preliminary evidence suggests these should include trials of psychological group interventions and piribedil.

Indexed as

Anti-Inflammatory Agents, Non-SteroidalCholinesterase InhibitorsCognitive Behavioral TherapyCognitive DysfunctionDopamine AgonistsDrugs, Chinese HerbalExercise TherapyFatty Acids, Omega-3Ginkgo bilobaHumansNicotineNicotinic AgonistsPhytotherapyPiribedilPsychotherapy, GroupQuality of LifeAnti-Inflammatory Agents, Non-SteroidalCholinesterase InhibitorsDopamine AgonistsDrugs, Chinese HerbalFatty Acids, Omega-3NicotineNicotinic AgonistsPiribedilVitamins

Identifiers

PMID24085737
PMCPMC3943830
OpenAlexW2107636641

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.