ArticleJournal of cancer research and clinical oncology2013
Impact of chemotherapy and radiotherapy in childhood on fertility in adulthood: the FeCt-survey of childhood cancer survivors in Germany.
Article in Journal of cancer research and clinical oncology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 3 syntheses or guidelines pooled it, 61 citations in OpenAlex.
- ESHRE good practice recommendations on fertility preservation involving testicular tissue cryopreservation in children receiving gonadotoxic therapies†.Human reproduction (Oxford, England) · 2025Guideline
- Impacts of platinum-based chemotherapy on subsequent testicular function and fertility in boys with cancer.Human reproduction update · 2020Pooled it
- Exposure to radiation therapy is associated with female reproductive health among childhood cancer survivors: a meta-analysis study.Journal of assisted reproduction and genetics · 2015Pooled it
- Fertility Preservation in Pediatric Oncology: Results of a Single-Center Retrospective Study (2000-2018).Cancers · 2025Article
- Fertility, gonadal and sexual function in survivors of nasopharyngeal carcinoma patients.BMC cancer · 2025Article
- Non-alkylating agents-induced gonadotoxicity in pre-pubertal males: Insights on the clinical and pre-clinical front.Clinical and translational science · 2024Review
- Ovarian function in female survivors of high-risk neuroblastoma.Pediatric blood & cancer · 2024Article
- Article
- An Educational Need Regarding Treatment-Related Infertility and Fertility Preservation: a National Survey Among Members of the Dutch Society for Medical Oncologists.Journal of cancer education : the official journal of the American Association for Cancer Education · 2023Article
- Primary vaginal endodermal sinus tumor in infants and children: experience from a tertiary center.BMC pediatrics · 2022Article
- Effect of Neuroendocrine Neoplasm Treatment on Human Reproductive Health and Sexual Function.Journal of clinical medicine · 2022Review
- [The 41,000 long-term survivor cohort of the German Childhood Cancer Registry].Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz · 2022Article
- Oncofertility in pediatric patients: current perspectives.Contemporary oncology (Poznan, Poland) · 2022Review
- Diagnosis Difficulties and Minimally Invasive Treatment for Ovarian Masses in Adolescents.International journal of women's health · 2022Article
- A cross-sectional examination of caregiver mental health and childhood cancer survivors' tobacco, alcohol, and marijuana use.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2021Article
- DNA Damaged Induced Cell Death in Oocytes.Molecules (Basel, Switzerland) · 2020Review
- Ambulant health care utilisation among children of childhood cancer survivors in Germany.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2020Article
- Uterine irradiation as a determinant of infertility and pregnancy losses in young cancer survivors.Ecancermedicalscience · 2020Review
- Fertility Among Female Survivors of Childhood, Adolescent, and Young Adult Cancer: Protocol for Two Pan-European Studies (PanCareLIFE).JMIR research protocols · 2018Article
- Urological issues arising after treatment of pediatric malignancies.Canadian Urological Association journal = Journal de l'Association des urologues du Canada · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeImproved treatment for childhood cancer has led to better survival rates of 83 % today. However, long-term side effects including infertility of pediatric patients receiving oncologic treatment remain unclear. We examined the association of chemotherapy and radiotherapy with infertility in survivors of pediatric cancer.
methodsA questionnaire on fertility was sent to adult survivors listed in the German Childhood Cancer Registry. Fertility status was defined based on information on attempts to conceive, pregnancies, births, menstrual cycle and previous fertility test results.
resultsTherapeutic data were obtained from treatment optimization trials. We included 618 childhood cancer survivors (384 women) who reported information allowing us to classify their current fertility status as 'fertile/probably fertile' or 'probably infertile'. Thirty-one percent of 83 female and 29 % of 117 male survivors reported infertility based on previous fertility tests. 'Probably infertile' adult survivors were more likely to have received pelvic radiotherapy (women: adjusted OR 20.24, 95 % CI 4.69-87.29; men: 12.22; 1.18-126.70) than those who were 'fertile/probably fertile'. Etoposide, particularly ≥5,000 mg/m(2) in women, and carboplatin and/or cisplatin in both sexes seemed to have independent risk potential for infertility. Similarly, cancer treatment during or post-puberty compared to treatment before puberty showed a trend toward increased infertility, particularly in male survivors.
conclusionsPatients and families need to be informed about fertility-preserving measures prior to and also after chemotherapy and radiotherapy.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.