Trial reportCell stress & chaperones2014
Extracellular Hsp72 concentration relates to a minimum endogenous criteria during acute exercise-heat exposure.
Trial report in Cell stress & chaperones, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it, 67 citations in OpenAlex.
- Passive heating and glycaemic control in non-diabetic and diabetic individuals: A systematic review and meta-analysis.PloS one · 2019Pooled it
- Moderate- and high-intensity exhaustive exercise in the heat induce a similar increase in monocyte Hsp72.Cell stress & chaperones · 2015Trial
- Human monocyte heat shock protein 72 responses to acute hypoxic exercise after 3 days of exercise heat acclimation.BioMed research international · 2015Trial
- Repeated Sprint Training in Heat Improves Repeated Sprint Ability Under Temperate Conditions Similarly in Active Males and Females.European journal of sport science · 2026Article
- Comparison of heat acclimation after once daily and thrice daily heat exposures in healthy adults.Physiological reports · 2026Article
- Comparing the effects of a 7-week repeated sprint training in hypoxia vs. heat in males and females.Frontiers in sports and active living · 2026Article
- Effects of heat stimulation after high-intensity interval training on serum adipokines, eHSP72, and immunoglobulins in men with obesity.Journal of exercise science and fitness · 2025Article
- Comparison of thermoregulatory, cardiovascular, and immune responses to different passive heat therapy modalities.American journal of physiology. Regulatory, integrative and comparative physiology · 2025Article
- Differential intestinal injury and unchanged systemic inflammatory responses to leg and whole-body passive hyperthermia in healthy humans.Experimental physiology · 2025Article
- Molecular biomarkers for assessing the heat-adapted phenotype: a narrative scoping review.The journal of physiological sciences : JPS · 2023Article
- Carbohydrate, but not fat, oxidation is reduced during moderate-intensity exercise performed in 33 vs. 18 °C at matched heart rates.European journal of applied physiology · 2023Article
- Heart Rate and Body Temperature Evolution in an Interval Program of Passive Heat Acclimation at High Temperatures (100 ± 2 °C) in a Sauna.International journal of environmental research and public health · 2023Article
- Drug-Induced Hyperthermia Review.Cureus · 2022Review
- Heat shock protein response during fixed intensity and self-paced exercise in the heat in young, healthy women on oral contraceptives compared with young healthy men.South African journal of sports medicine · 2022Article
- Heat therapy: mechanistic underpinnings and applications to cardiovascular health.Journal of applied physiology (Bethesda, Md. : 1985) · 2021Review
- A protocol for an observational cohort study of heat strain and its effect on fetal wellbeing in pregnant farmers in The Gambia.Wellcome open research · 2020Article
- Heat acclimation attenuates the increased sensations of fatigue reported during acute exercise-heat stress.Temperature (Austin, Tex.) · 2019Article
- Intermittent sprint performance in the heat is not altered by augmenting thermal perception via L-menthol or capsaicin mouth rinses.European journal of applied physiology · 2019Article
- Application of evidence-based recommendations for heat acclimation: Individual and team sport perspectives.Temperature (Austin, Tex.) · 2019Review
- Could Heat Therapy Be an Effective Treatment for Alzheimer's and Parkinson's Diseases? A Narrative Review.Frontiers in physiology · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Extracellular heat shock protein 72 (eHsp72) concentration increases during exercise-heat stress when conditions elicit physiological strain. Differences in severity of environmental and exercise stimuli have elicited varied response to stress. The present study aimed to quantify the extent of increased eHsp72 with increased exogenous heat stress, and determine related endogenous markers of strain in an exercise-heat model. Ten males cycled for 90 min at 50 % [Formula: see text] in three conditions (TEMP, 20 °C/63 % RH; HOT, 30.2 °C/51%RH; VHOT, 40.0 °C/37%RH). Plasma was analysed for eHsp72 pre, immediately post and 24-h post each trial utilising a commercially available ELISA. Increased eHsp72 concentration was observed post VHOT trial (+172.4 %) (p < 0.05), but not TEMP (-1.9 %) or HOT (+25.7 %) conditions. eHsp72 returned to baseline values within 24 h in all conditions. Changes were observed in rectal temperature (Trec), rate of Trec increase, area under the curve for Trec of 38.5 and 39.0 °C, duration Trec ≥38.5 and ≥39.0 °C, and change in muscle temperature, between VHOT, and TEMP and HOT, but not between TEMP and HOT. Each condition also elicited significantly increasing physiological strain, described by sweat rate, heart rate, physiological strain index, rating of perceived exertion and thermal sensation. Stepwise multiple regression reported rate of Trec increase and change in Trec to be predictors of increased eHsp72 concentration. Data suggests eHsp72 concentration increases once systemic temperature and sympathetic activity exceeds a minimum endogenous criteria elicited during VHOT conditions and is likely to be modulated by large, rapid changes in core temperature.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.