ReviewBiogerontology2013
Tissue resident stem cells: till death do us part.
Review in Biogerontology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed.
- Stem cells in organogenesis and regeneration.Stem cell research & therapy · 2026Review
- Anti-ceramide Single-Chain Variable Fragment Mitigates Gastrointestinal-Acute Radiation Syndrome and Improves Marrow Reconstitution, Rendering Near-Normal 90-Day Autopsies.International journal of radiation oncology, biology, physics · 2024Article
- Chemotherapy-Mediated Complications of Wound Healing: An Understudied Side Effect.Advances in wound care · 2024Review
- Functional Genomic Screening During Somatic Cell Reprogramming Identifies DKK3 as a Roadblock of Organ Regeneration.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021Article
- Cell division rates decrease with age, providing a potential explanation for the age-dependent deceleration in cancer incidence.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- The Pro-reparative Engine: Stem Cells Aid Healing by Dampening Inflammation.Current pathobiology reports · 2018Article
- Stem cells and anti-aging genes: double-edged sword-do the same job of life extension.Stem cell research & therapy · 2018Review
- Transplantation of mesenchymal stem cells reverses behavioural deficits and impaired neurogenesis caused by prenatal exposure to valproic acid.Oncotarget · 2017Article
- Changes in the methylation status of the Oct3/4, Nanog, and Sox2 promoters in stem cells during regeneration of rat tracheal epithelium after injury.Oncotarget · 2017Article
- Cellular Senescence and Lung Function during Aging. Yin and Yang.Annals of the American Thoracic Society · 2016Review
- From restoration to regeneration: periodontal aging and opportunities for therapeutic intervention.Periodontology 2000 · 2016Review
- Mesenchymal Stromal Cells and Tissue-Specific Progenitor Cells: Their Role in Tissue Homeostasis.Stem cells international · 2016Review
- Mesenchymal stem cell aging: Mechanisms and influences on skeletal and non-skeletal tissues.Experimental biology and medicine (Maywood, N.J.) · 2015Review
- SHIP1-expressing mesenchymal stem cells regulate hematopoietic stem cell homeostasis and lineage commitment during aging.Stem cells and development · 2015Article
- The crossroads between cancer stem cells and aging.BMC cancer · 2015Review
- Agonists of growth hormone-releasing hormone stimulate self-renewal of cardiac stem cells and promote their survival.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Cells of renin lineage take on a podocyte phenotype in aging nephropathy.American journal of physiology. Renal physiology · 2014Article
- Glioblastoma stem cells: Molecular characteristics and therapeutic implications.World journal of stem cells · 2014Review
- Age associated communication between cells and matrix: a potential impact on stem cell-based tissue regeneration strategies.Organogenesis · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aging is accompanied by reduced regenerative capacity of all tissues and organs and dysfunction of adult stem cells. Notably, these age-related alterations contribute to distinct pathophysiological characteristics depending on the tissue of origin and function and thus require special attention in a type by type manner. In this paper, we review the current understanding of the mechanisms leading to tissue-specific adult stem cell dysfunction and reduced regenerative capacity with age. A comprehensive investigation of the hematopoietic, the neural, the mesenchymal, and the skeletal stem cells in age-related research highlights that distinct mechanisms are associated with the different types of tissue stem cells. The link between age-related stem cell dysfunction and human pathologies is discussed along with the challenges and the future perspectives in stem cell-based therapies in age-related diseases.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.