ArticleEuropean journal of nuclear medicine and molecular imaging2014
Quantitative assessment of global lung inflammation following radiation therapy using FDG PET/CT: a pilot study.
Article in European journal of nuclear medicine and molecular imaging, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 55 citations in OpenAlex.
- [European journal of nuclear medicine and molecular imaging · 2026Article
- The value of FDG-PET/CT imaging in the assessment, monitoring, and management of COVID-19.European physical journal plus · 2023Review
- Evaluation of [Molecular imaging and biology · 2022Article
- IntegratingThoracic cancer · 2022Article
- Diagnostic Value ofFrontiers in oncology · 2022Article
- Promising Biomarkers of Radiation-Induced Lung Injury: A Review.Biomedicines · 2021Review
- The critical role of FDG-PET/CT imaging in assessing systemic manifestations of COVID-19 infection.European journal of nuclear medicine and molecular imaging · 2021Article
- Implementation of FDG-PET/CT imaging methodology for quantification of inflammatory response in patients with locally advanced non-small cell lung cancer: results from the ACRIN 6668/RTOG 0235 trial.American journal of nuclear medicine and molecular imaging · 2021Article
- Reinventing Molecular Imaging with Total-Body PET, Part II: Clinical Applications.PET clinics · 2020Review
- Granulomatous-Lymphocytic Interstitial Lung Disease in Common Variable Immunodeficiency-Features of CT andFrontiers in immunology · 2020Observational
- Article
- Prognostic value of volumetric metabolic parameter changes determined by during and after radiotherapy-basedThe Kaohsiung journal of medical sciences · 2019Article
- Pretreatment volumetric parameters of FDG-PET predict the survival after Yttrium-90 radio-embolization in metastatic liver disease.American journal of nuclear medicine and molecular imaging · 2019Article
- A prospective study of the feasibility of FDG-PET/CT imaging to quantify radiation-induced lung inflammation in locally advanced non-small cell lung cancer patients receiving proton or photon radiotherapy.European journal of nuclear medicine and molecular imaging · 2019Article
- What can be and what cannot be accomplished with PET to detect and characterize atherosclerotic plaques.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2018Article
- Correlation of Functional Lung Heterogeneity and Dosimetry to Radiation Pneumonitis using Perfusion SPECT/CT and FDG PET/CT Imaging.International journal of radiation oncology, biology, physics · 2018Article
- Prognostic role of serial quantitative evaluation ofEuropean journal of nuclear medicine and molecular imaging · 2018Article
- Patient-reported lung symptoms as an early signal of impending radiation pneumonitis in patients with non-small cell lung cancer treated with chemoradiation: an observational study.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2018Observational
- Approaches to Evaluate Lung Inflammation in Translational Research.Veterinary pathology · 2018Review
- Anatomic, functional and molecular imaging in lung cancer precision radiation therapy: treatment response assessment and radiation therapy personalization.Translational lung cancer research · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeRadiation pneumonitis is the most severe dose-limiting complication in patients receiving thoracic radiation therapy. The aim of this study was to quantify global lung inflammation following radiation therapy using FDG PET/CT.
methodsWe studied 20 subjects with stage III non-small-cell lung carcinoma who had undergone FDG PET/CT imaging before and after radiation therapy. On all PET/CT studies, the sectional lung volume (sLV) of each lung was calculated from each slice by multiplying the lung area by slice thickness. The sectional lung glycolysis (sLG) was calculated by multiplying the sLV and the lung sectional mean standardized uptake value (sSUVmean) on each slice passing through the lung. The lung volume (LV) was calculated by adding all sLVs from the lung, and the global lung glycolysis (GLG) was calculated by adding all sLGs from the lung. Finally, the lung SUVmean was calculated by dividing the GLG by the LV. The amount of inflammation in the lung parenchyma directly receiving radiation therapy was calculated by subtracting tumor measurements from GLG.
resultsIn the lung directly receiving radiation therapy, the lung parenchyma SUVmean and global lung parenchymal glycolysis were significantly increased following therapy. In the contralateral lung (internal control), no significant changes were observed in lung SUVmean or GLG following radiation therapy.
conclusionGlobal lung parenchymal glycolysis and lung parenchymal SUVmean may serve as potentially useful biomarkers to quantify lung inflammation on FDG PET/CT following thoracic radiation therapy.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.