ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2014
Reduced anterior temporal and hippocampal functional connectivity during face processing discriminates individuals with social anxiety disorder from healthy controls and panic disorder, and increases following treatment.
Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 2 of them syntheses that pooled it.
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Who cites it
29 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Candidate Biological Markers for Social Anxiety Disorder: A Systematic Review.International journal of molecular sciences · 2023Pooled it
- Beyond emotions: A meta-analysis of neural response within face processing system in social anxiety.Experimental biology and medicine (Maywood, N.J.) · 2016Pooled it
- Amygdala activity after subchronic escitalopram administration in healthy volunteers: A pharmaco-functional magnetic resonance imaging study.Journal of psychopharmacology (Oxford, England) · 2024Trial
- Why are you looking at me like that? Intolerance of uncertainty and emotional face processing in social anxiety disorder.NeuroImage. Clinical · 2026Article
- Relationship between BDNF rs6265 (VAL66MET) polymorphism and serum BDNF LEVELS in anxiety disorders.Molecular biology reports · 2026Article
- Distinct Cortical Activation in Adolescents With Social Anxiety Disorder: An fNIRS Study.Brain and behavior · 2026Article
- Brain structural alterations associated with impulsiveness in male violent patients with schizophrenia.BMC psychiatry · 2024Article
- Exploring Neural Correlates between Anxiety and Inhibitory Ability: Evidence from Task-Based fNIRS.Depression and anxiety · 2024Article
- Structural connectome alterations in anxious dogs: a DTI-based study.Scientific reports · 2023Article
- A Semantic Cognition Contribution to Mood and Anxiety Disorder Pathophysiology.Healthcare (Basel, Switzerland) · 2023Review
- Altered functional connectivity of nucleus accumbens subregions associates with non-motor symptoms in Parkinson's disease.CNS neuroscience & therapeutics · 2022Article
- Neurocircuitry of treatment in anxiety disorders.Biomarkers in neuropsychiatry · 2022Article
- ENIGMA-anxiety working group: Rationale for and organization of large-scale neuroimaging studies of anxiety disorders.Human brain mapping · 2022Review
- Emerging Evidence for Putative Neural Networks and Antecedents of Pediatric Anxiety in the Fetal, Neonatal, and Infant Periods.Biological psychiatry · 2021Review
- Fear-induced brain activations distinguish anxious and trauma-exposed brains.Translational psychiatry · 2021Article
- Toward Robust Anxiety Biomarkers: A Machine Learning Approach in a Large-Scale Sample.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2020Article
- Classification of Social Anxiety Disorder With Support Vector Machine Analysis Using Neural Correlates of Social Signals of Threat.Frontiers in psychiatry · 2020Article
- Hippocampal Shape Maturation in Childhood and Adolescence.Cerebral cortex (New York, N.Y. : 1991) · 2019Article
- Dissociation between Cerebellar and Cerebral Neural Activities in Humans with Long-Term Bilateral Sensorineural Hearing Loss.Neural plasticity · 2019Article
- Hippocampal-Temporopolar Connectivity Contributes to Episodic Simulation During Social Cognition.Scientific reports · 2018Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Group functional magnetic resonance imaging (fMRI) studies suggest that anxiety disorders are associated with anomalous brain activation and functional connectivity (FC). However, brain-based features sensitive enough to discriminate individual subjects with a specific anxiety disorder and that track symptom severity longitudinally, desirable qualities for putative disorder-specific biomarkers, remain to be identified. Blood oxygen level-dependent (BOLD) fMRI during emotional face perceptual tasks and a new, large-scale and condition-dependent FC and machine learning approach were used to identify features (pair-wise correlations) that discriminated patients with social anxiety disorder (SAD, N=16) from controls (N=19). We assessed whether these features discriminated SAD from panic disorder (PD, N=16), and SAD from controls in an independent replication sample that performed a similar task at baseline (N: SAD=15, controls=17) and following 8-weeks paroxetine treatment (N: SAD=12, untreated controls=7). High SAD vs HCs discrimination (area under the ROC curve, AUC, arithmetic mean of sensitivity and specificity) was achieved with two FC features during unattended neutral face perception (AUC=0.88, P<0.05 corrected). These features also discriminated SAD vs PD (AUC=0.82, P=0.0001) and SAD vs HCs in the independent replication sample (FC during unattended angry face perception, AUC=0.71, P=0.01). The most informative FC was left hippocampus-left temporal pole, which was reduced in both SAD samples (replication sample P=0.027), and this FC increased following the treatment (post>pre, t(11)=2.9, P=0.007). In conclusion, SAD is associated with reduced FC between left temporal pole and left hippocampus during face perception, and results suggest promise for emerging FC-based biomarkers for SAD diagnosis and treatment effects.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.