ArticleThe American journal of psychiatry2013
Maternal smoking during pregnancy and bipolar disorder in offspring.
Article in The American journal of psychiatry, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
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Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 107 citations in OpenAlex.
- Prenatal tobacco use and the risk of mood disorders in offspring: a systematic review and meta-analysis.Social psychiatry and psychiatric epidemiology · 2020Pooled it
- Pooled it
- Linking epidemiology and genomics of maternal smoking during pregnancy in utero and in ageing: a population-based study using human foetuses and the UK Biobank cohort.EBioMedicine · 2025Article
- Impaired neural stress resistance and loss of REST in bipolar disorder.Molecular psychiatry · 2024Article
- DNA methylation as a potential mediator of the association between prenatal tobacco and alcohol exposure and child neurodevelopment in a South African birth cohort.Translational psychiatry · 2022Article
- The detrimental effects of smoking on the course and outcome in adults with bipolar disorder-A narrative review.Frontiers in psychiatry · 2022Review
- Oxidative Stress Impact on the Transcriptome of Differentiating Neuroblastoma Cells: Implication for Psychiatric Disorders.International journal of molecular sciences · 2020Article
- DNA methylation links prenatal smoking exposure to later life health outcomes in offspring.Clinical epigenetics · 2019Article
- Aggressive behaviour in childhood and adolescence: the role of smoking during pregnancy, evidence from four twin cohorts in the EU-ACTION consortium.Psychological medicine · 2019Article
- Examining the Association Between Maternal Smoking During Pregnancy and Child Behavior Problems Using Quality-Adjusted Life Years.Maternal and child health journal · 2018Article
- Maternal serum cytokine levels and risk of bipolar disorder.Brain, behavior, and immunity · 2017Article
- Association Between Maternal Smoking During Pregnancy and Severe Mental Illness in Offspring.JAMA psychiatry · 2017Article
- Recent advances in the understanding and management of bipolar disorder in adults.F1000Research · 2017Review
- Environmental factors, life events, and trauma in the course of bipolar disorder.Psychiatry and clinical neurosciences · 2017Review
- Geographic Variation in Maternal Smoking during Pregnancy in the Missouri Adolescent Female Twin Study (MOAFTS).PloS one · 2016Article
- Associations between residence at birth and mental health disorders: a spatial analysis of retrospective cohort data.BMC public health · 2015Article
- Is maternal smoking during pregnancy associated with bipolar disorder in offspring?Journal of affective disorders · 2015Article
- Commentary: Smoking in pregnancy and offspring health: early insights into family-based and 'negative control' studies?International journal of epidemiology · 2014Article
- Fluoxetine treatment ameliorates depression induced by perinatal arsenic exposure via a neurogenic mechanism.Neurotoxicology · 2014Article
- Perinatal factors and the risk of bipolar disorder in Finland.Journal of affective disorders · 2014Article
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6 authors at 4 institutions in 1 country.
Funding
Abstract
objectiveMaternal smoking during pregnancy is associated with a number of adverse externalizing outcomes for offspring from childhood to adulthood. The relationship between maternal smoking and bipolar disorder in offspring, which includes externalizing symptoms among its many manifestations, has not been investigated in depth. The authors examined whether offspring exposed to maternal smoking in utero would be at increased lifetime risk for bipolar disorder after accounting for other factors related to maternal smoking.
methodIndividuals with bipolar disorder (N=79) were ascertained from the birth cohort of the Child Health and Development Study. Case subjects were identified by a combination of clinical, database, and direct mailing sources; all case subjects were directly interviewed and diagnosed using DSM-IV criteria. Comparison subjects (N=654) were matched to case subjects on date of birth (±30 days), sex, membership in the cohort at the time of illness onset, and availability of maternal archived sera.
resultsAfter adjusting for potential confounders, offspring exposed to in utero maternal smoking exhibited a twofold greater risk for bipolar disorder (odds ratio=2.014, 95% confidence interval=1.48-2.53, p=0.01). The associations were noted primarily among bipolar offspring without psychotic features.
conclusionsPrenatal tobacco exposure may be one suspected cause of bipolar disorder. However, it will be necessary to account for other unmeasured familial factors before causal teratogenic effects can be suggested.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.