ArticleMarine drugs2013
Functional genomics of novel secondary metabolites from diverse cyanobacteria using untargeted metabolomics.
Article in Marine drugs, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- The Importance ofMicroorganisms · 2026Article
- The natural history of a biocrust architect, the cyanobacterium Microcoleus vaginatus.FEMS microbiology reviews · 2026Review
- Overlooked Vital Role of Persistent Algae-Bacteria Interaction in Ocean Recalcitrant Carbon Sequestration and Its Response to Ocean Warming.Global change biology · 2024Article
- Nimble vs. torpid responders to hydration pulse duration among soil microbes.Communications biology · 2024Article
- The Glutathione System: A Journey from Cyanobacteria to Higher Eukaryotes.Antioxidants (Basel, Switzerland) · 2023Review
- ProX from marine Synechococcus spp. show a sole preference for glycine-betaine with differential affinity between ecotypes.Environmental microbiology · 2022Article
- Untargeted GC-MS reveals differential regulation of metabolic pathways in cyanobacteriumCurrent research in microbial sciences · 2022Article
- Phytoplankton exudates and lysates support distinct microbial consortia with specialized metabolic and ecophysiological traits.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Final Destination? PinpointingLife (Basel, Switzerland) · 2021Article
- Article
- A symbiotic nutrient exchange within the cyanosphere microbiome of the biocrust cyanobacterium, Microcoleus vaginatus.The ISME journal · 2021Article
- The biology of ergothioneine, an antioxidant nutraceutical.Nutrition research reviews · 2020Review
- Article
- Method development and validation for the quantification of organic acids in microbial samples using anionic exchange solid-phase extraction and gas chromatography-mass spectrometry.Analytical and bioanalytical chemistry · 2020Article
- Article
- Insights into the Metabolome of the CyanobacteriumMetabolites · 2020Article
- Profiling of Small Molecular Metabolites inMarine drugs · 2019Article
- Article
- Day and Night: Metabolic Profiles and Evolutionary Relationships of Six Axenic Non-Marine Cyanobacteria.Genome biology and evolution · 2019Article
- The Colorful World of Extracellular Electron Shuttles.Annual review of microbiology · 2017Review
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mass spectrometry-based metabolomics has become a powerful tool for the detection of metabolites in complex biological systems and for the identification of novel metabolites. We previously identified a number of unexpected metabolites in the cyanobacterium Synechococcus sp. PCC 7002, such as histidine betaine, its derivatives and several unusual oligosaccharides. To test for the presence of these compounds and to assess the diversity of small polar metabolites in other cyanobacteria, we profiled cell extracts of nine strains representing much of the morphological and evolutionary diversification of this phylum. Spectral features in raw metabolite profiles obtained by normal phase liquid chromatography coupled to mass spectrometry (MS) were manually curated so that chemical formulae of metabolites could be assigned. For putative identification, retention times and MS/MS spectra were cross-referenced with those of standards or available sprectral library records. Overall, we detected 264 distinct metabolites. These included indeed different betaines, oligosaccharides as well as additional unidentified metabolites with chemical formulae not present in databases of metabolism. Some of these metabolites were detected only in a single strain, but some were present in more than one. Genomic interrogation of the strains revealed that generally, presence of a given metabolite corresponded well with the presence of its biosynthetic genes, if known. Our results show the potential of combining metabolite profiling and genomics for the identification of novel biosynthetic genes.
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