ArticleHeredity2014
Deciphering the fine-structure of tribal admixture in the Bedouin population using genomic data.
Article in Heredity, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 26 citations in OpenAlex.
- SCAPER localizes to primary cilia and its mutation affects cilia length, causing Bardet-Biedl syndrome.European journal of human genetics : EJHG · 2019Trial
- A Pangenomic Approach to Improve Population Genetics Analysis and Reference Bias in Underrepresented Middle Eastern and Horn of Africa Populations.Biomolecules · 2025Article
- Founder mutations and rare disease in the Arab world.Disease models & mechanisms · 2024Review
- Article
- A syndrome of severe intellectual disability, hypotonia, failure to thrive, dysmorphism, and thinning of corpus callosum maps to chromosome 7q21.13-q21.3.Clinical genetics · 2022Article
- Bioarchaeological evidence of one of the earliest Islamic burials in the Levant.Communications biology · 2022Article
- Novel MTMR2 mutation causing severe Charcot-Marie-Tooth type 4B1 disease: a case report.Neurogenetics · 2020Article
- Population structure and inherited genetic disorders in the Bedouin of the Negev.Journal of community genetics · 2020Article
- Heterozygous versus homozygous phenotype caused by the same MC4R mutation: novel mutation affecting a large consanguineous kindred.BMC medical genetics · 2018Article
- SLC30A9 mutation affecting intracellular zinc homeostasis causes a novel cerebro-renal syndrome.Brain : a journal of neurology · 2017Article
- A Rare Variant inBioMed research international · 2017Article
- Indigenous Arabs are descendants of the earliest split from ancient Eurasian populations.Genome research · 2016Article
- A syndrome of congenital microcephaly, intellectual disability and dysmorphism with a homozygous mutation in FRMD4A.European journal of human genetics : EJHG · 2015Article
- Kuwaiti population subgroup of nomadic Bedouin ancestry-Whole genome sequence and analysis.Genomics data · 2015Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Bedouin Israeli population is highly inbred and structured with a very high prevalence of recessive diseases. Many studies in the past two decades focused on linkage analysis in large, multiple consanguineous pedigrees of this population. The advent of high-throughput technologies motivated researchers to search for rare variants shared between smaller pedigrees, integrating data from clinically similar yet seemingly non-related sporadic cases. However, such analyses are challenging because, without pedigree data, there is no prior knowledge regarding possible relatedness between the sporadic cases. Here, we describe models and techniques for the study of relationships between pedigrees and use them for the inference of tribal co-ancestry, delineating the complex social interactions between different tribes in the Negev Bedouins of southern Israel. Through our analysis, we differentiate between tribes that share many yet small genomic segments because of co-ancestry versus tribes that share larger segments because of recent admixture. The emergent pattern is well correlated with the prevalence of rare mutations in the different tribes. Tribes that do not intermarry, mostly because of social restrictions, hold private mutations, whereas tribes that do intermarry demonstrate a genetic flow of mutations between them. Thus, social structure within an inbred community can be delineated through genomic data, with implications to genetic counseling and genetic mapping.
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