ArticleJournal of visualized experiments : JoVE2013
An orthotopic murine model of human prostate cancer metastasis.
Article in Journal of visualized experiments : JoVE, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 30 citations in OpenAlex.
- A Preliminary Evaluation ofPharmaceutics · 2026Article
- Inhibition of orthotopic castration-resistant prostate cancer growth and metastasis in mice by JC VLPs carrying a suicide gene driven by the PSA promoter.Cancer gene therapy · 2024Article
- Spatial distribution of tumor-associated macrophages in an orthotopic prostate cancer mouse model.Pathology oncology research : POR · 2024Article
- Tracking Tumor Cell Dissemination from Lung Metastases Using Photoconversion.Journal of visualized experiments : JoVE · 2023Article
- Development of a novel regenerative therapy for malignant bone tumors using an autograft containing tumor inactivated by high hydrostatic pressurization (HHP).Regenerative therapy · 2023Article
- Feasibility and guidelines for the use of an injectable fiducial marker (BioXmarkF1000Research · 2023Article
- Optimization and Characterization of a Bone Culture Model to Study Prostate Cancer Bone Metastasis.Molecular cancer therapeutics · 2022Article
- Article
- CT vs. bioluminescence: A comparison of imaging techniques for orthotopic prostate tumors in mice.PloS one · 2022Article
- A Humanized Monoclonal Antibody Targeting Extracellular Nicotinamide Phosphoribosyltransferase Prevents Aggressive Prostate Cancer Progression.Pharmaceuticals (Basel, Switzerland) · 2021Article
- Correction: Inhibitor SBFI26 suppresses the malignant progression of castration-resistant PC3-M cells by competitively binding to oncogenic FABP5.Oncotarget · 2020Article
- Development of Zinc-Specific iCEST MRI as an Imaging Biomarker for Prostate Cancer.Angewandte Chemie (International ed. in English) · 2019Article
- Comparative Study of Subcutaneous and Orthotopic Mouse Models of Prostate Cancer: Vascular Perfusion, Vasculature Density, Hypoxic Burden and BB2r-Targeting Efficacy.Scientific reports · 2019Article
- Inactivated FABP5 suppresses malignant progression of prostate cancer cells by inhibiting the activation of nuclear fatty acid receptor PPARγ.Genes & cancer · 2019Article
- Humanization of the Prostate Microenvironment Reduces Homing of PC3 Prostate Cancer Cells to Human Tissue-Engineered Bone.Cancers · 2018Article
- Precision therapeutic targeting of human cancer cell motility.Nature communications · 2018Article
- Cholesterol Esterification Inhibition Suppresses Prostate Cancer Metastasis by Impairing the Wnt/β-catenin Pathway.Molecular cancer research : MCR · 2018Article
- Characterization of an Orthotopic Colorectal Cancer Mouse Model and Its Feasibility for Accurate Quantification in Positron Emission Tomography.Molecular imaging and biology · 2017Article
- T-box 3 overexpression is associated with poor prognosis of non-small cell lung cancer.Oncology letters · 2017Article
- Pre-clinical Orthotopic Murine Model of Human Prostate Cancer.Journal of visualized experiments : JoVE · 2016Article
Corrections and comments
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Authors and funding
3 authors at 1 institution.
Funding
Abstract
Our laboratory has developed a novel orthotopic implantation model of human prostate cancer (PCa). As PCa death is not due to the primary tumor, but rather the formation of distinct metastasis, the ability to effectively model this progression pre-clinically is of high value. In this model, cells are directly implanted into the ventral lobe of the prostate in Balb/c athymic mice, and allowed to progress for 4-6 weeks. At experiment termination, several distinct endpoints can be measured, such as size and molecular characterization of the primary tumor, the presence and quantification of circulating tumor cells in the blood and bone marrow, and formation of metastasis to the lung. In addition to a variety of endpoints, this model provides a picture of a cells ability to invade and escape the primary organ, enter and survive in the circulatory system, and implant and grow in a secondary site. This model has been used effectively to measure metastatic response to both changes in protein expression as well as to response to small molecule therapeutics, in a short turnaround time.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.