ReviewThe Journal of allergy and clinical immunology2014
A molecular perspective on TH2-promoting cytokine receptors in patients with allergic disease.
Review in The Journal of allergy and clinical immunology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 50 citations in OpenAlex.
- Comparative Efficacy and Safety of Dupilumab and Benralizumab in Patients with Inadequately Controlled Asthma: A Systematic Review.International journal of molecular sciences · 2020Pooled it
- An in silico approach to peptide-based dual-receptor targeting for IL13RA2 and VEGFR-2 extracellular domain.Journal of molecular modeling · 2026Article
- Rhinovirus as a driver of airway T cell dynamics in children with treatment-refractory recurrent wheeze.JCI insight · 2025Article
- Modulation of IL-4/IL-13 cytokine signaling in the context of allergic disease.The Journal of allergy and clinical immunology · 2022Review
- Interleukin-5 receptor alpha (CD125) expression on human blood and lung neutrophils.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2022Article
- Predicting the allergenicity of legume proteins using a PBMC gene expression assay.BMC immunology · 2021Article
- Dectin-1 Controls TSLP-Induced Th2 Response by Regulating STAT3, STAT6, and p50-RelB Activities in Dendritic Cells.Frontiers in immunology · 2021Article
- Report from the National Institute of Allergy and Infectious Diseases workshop on "Atopic dermatitis and the atopic march: Mechanisms and interventions".The Journal of allergy and clinical immunology · 2019Article
- Article
- Leptin Promotes Allergic Airway Inflammation through Targeting the Unfolded Protein Response Pathway.Scientific reports · 2018Article
- TThe Journal of allergy and clinical immunology · 2018Article
- Urinary Peptides As a Novel Source of T Cell Allergen Epitopes.Frontiers in immunology · 2018Article
- Pathogenic CD4The Journal of allergy and clinical immunology · 2017Review
- 100 Years later: Celebrating the contributions of x-ray crystallography to allergy and clinical immunology.The Journal of allergy and clinical immunology · 2015Review
- IL-3 synergises with basophil-derived IL-4 and IL-13 to promote the alternative activation of human monocytes.European journal of immunology · 2015Article
- Reply: To PMID 24084078.The Journal of allergy and clinical immunology · 2014Article
- Structural basis of the proinflammatory signaling complex mediated by TSLP.Nature structural & molecular biology · 2014Article
- A case of adenomatous goiter involving diffuse, acute, and painful thyroid enlargement after fine-needle aspiration cytology.Case reports in endocrinology · 2014Article
- Influence of clinical factors, IL4 and IL6 genes polymorphisms in functional healing in late replantation.Brazilian dental journalArticle
- Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
The cytokines IL-4, IL-13, and thymic stromal lymphopoietin play a key role in allergic disease by virtue of their ability to initiate, maintain, and augment TH2 responses. These molecules mediate their effects through type 1 cytokine receptors, which bind cytokines with a characteristic structure. Receptors are expressed on a broad array of immune cell types and are integral to complex cytokine networks operating in health and disease. TH2-promoting cytokines bind different configurations of receptors. Receptor subunits can exist in surface-bound or soluble forms, as well as in isolation or in partnership with other subunits. Sharing of receptor subunits among different cytokine receptor complexes adds to the intricate landscape. This article describes the characteristics of receptors for IL-4, IL-13, and thymic stromal lymphopoietin and their respective ligands from a structure-function perspective. We detail the mechanisms of receptor complex assembly, the interrelated nature of these receptors, and the effect on allergic inflammation. The ability for novel and atypical types of receptors to modulate inflammatory processes is also discussed. We highlight current and emerging treatments that target TH2-promoting receptor complexes. Understanding the molecular features of these receptors provides insight into different disease phenotypes and the variable clinical outcomes arising from targeted therapies. These considerations can be used to inform future directions for research and creative strategies for treating individual patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.