ReviewNutrients2013
Nutrient intake values for folate during pregnancy and lactation vary widely around the world.
Review in Nutrients, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Preconception and Prenatal Nutrition and Neurodevelopmental Disorders: A Systematic Review and Meta-Analysis.Nutrients · 2019Pooled it
- The impact of MTHFR 677 C/T genotypes on folate status markers: a meta-analysis of folic acid intervention studies.European journal of nutrition · 2017Pooled it
- Impact of nutritional and multiple micronutrients supplementation to lactating mothers 6 months postpartum on the maternal and infant micronutrient status: a randomised controlled trial in Delhi, India.Public health nutrition · 2024Trial
- Maternal dietary folate imbalance alters cerebellar astrocyte morphology and density in offspring.IBRO neuroscience reports · 2025Article
- Article
- Risk of Excess Maternal Folic Acid Supplementation in Offspring.Nutrients · 2024Review
- Impact of maternal dietary folic acid or choline dietary deficiencies on vascular function in young and middle-aged female mouse offspring after ischemic stroke.American journal of physiology. Heart and circulatory physiology · 2023Article
- Dietary Vitamin B Complex: Orchestration in Human Nutrition throughout Life with Sex Differences.Nutrients · 2022Review
- Review
- Neuroprotective Role of Lactoferrin during Early Brain Development and Injury through Lifespan.Nutrients · 2022Review
- Enrichment characteristics and dietary evaluation of selenium in navel orange fruit from the largest navel orange-producing area in China (southern Jiangxi).Frontiers in plant science · 2022Article
- Multidimensional Approach to Assess Nutrition and Lifestyle in Breastfeeding Women during the First Month of Lactation.Nutrients · 2021Article
- Folic acid prevents functional and structural heart defects induced by prenatal ethanol exposure.American journal of physiology. Heart and circulatory physiology · 2021Article
- Variation of Gut Microbiome in Free-Ranging Female Tibetan Macaques (Animals : an open access journal from MDPI · 2020Article
- From Maternal Diet to Neurodevelopmental Disorders: A Story of Neuroinflammation.Frontiers in cellular neuroscience · 2020Review
- Successful Planned Pregnancy through Vitrified-Warmed Embryo Transfer in a Woman with Chronic Myeloid Leukemia: Case Report and Literature Review.Mediterranean journal of hematology and infectious diseases · 2020Article
- Effect of Sweet Corn Residue on Micronutrient Fortification in Baked Cakes.Foods (Basel, Switzerland) · 2019Article
- The Evaluation of Folic Acid-Deficient or Folic Acid-Supplemented Diet in the Gestational Phase of Female Rats and in Their Adult Offspring Subjected to an Animal Model of Schizophrenia.Molecular neurobiology · 2018Article
- The complete European guidelines on phenylketonuria: diagnosis and treatment.Orphanet journal of rare diseases · 2017Review
- Hypermethylation: Causes and Consequences in Skeletal Muscle Myopathy.Journal of cellular biochemistry · 2017Review
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Folate is a B-vitamin with particular importance during reproduction due to its role in the synthesis and maintenance of DNA. Folate is well known for its role in preventing neural tube defects (NTDs) during the periconceptional period. There is also an increased need for folate throughout pregnancy to support optimal growth and development of the fetus and blood volume expansion and tissue growth of the mother. During lactation, women are at risk of folate deficiency due to increased demands to accommodate milk folate levels. Nutrient Intake Values (NIVs) for folate have been calculated to take into account additional needs during pregnancy and lactation. However, these values vary widely between countries. For example, the folate requirement that is set to meet the needs of almost all healthy women during pregnancy varies from 300 µg/day in the United Kingdom to 750 µg/day in Mexico. Currently, there is no accepted standardized terminology or framework for establishing NIVs. This article reviews country-specific NIVs for folate during pregnancy and lactation and the basis for setting these reference values.
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Registered trials
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