ArticleTissue engineering. Part A2014
Engineered microvessels with strong alignment and high lumen density via cell-induced fibrin gel compaction and interstitial flow.
Article in Tissue engineering. Part A, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Short-Term Electrical Stimulation Impacts Cardiac Cell Structure and Function.Journal of tissue engineering and regenerative medicine · 2025Article
- A nanobody-guided multifunctional T cell engager promotes strong anti-tumor responses via synergistic immuno-photothermal effects.Journal of nanobiotechnology · 2024Article
- Fibrin-Based Hydrogels with Reactive Amphiphilic Copolymers for Mechanical Adjustments Allow for Capillary Formation in 2D and 3D Environments.Gels (Basel, Switzerland) · 2024Article
- Biofabrication of engineered blood vessels for biomedical applications.Science and technology of advanced materials · 2024Review
- 3D printed elastomeric biomaterial mitigates compaction during in vitro vasculogenesis.Acta biomaterialia · 2023Article
- Elucidating the signal for contact guidance contained in aligned fibrils with a microstructural-mechanical model.Journal of the Royal Society, Interface · 2022Article
- Cell contact guidance via sensing anisotropy of network mechanical resistance.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Review
- The Use of Tissue Engineering to Fabricate Perfusable 3D Brain MicrovesselsFrontiers in physiology · 2021Article
- Biomaterials for Bioprinting Microvasculature.Chemical reviews · 2020Review
- Harnessing neurovascular interaction to guide axon growth.Scientific reports · 2019Article
- Engineering stem cell cardiac patch with microvascular features representative of native myocardium.Theranostics · 2019Article
- Engineered cardiac tissue patch maintains structural and electrical properties after epicardial implantation.Biomaterials · 2018Article
- A cardiac patch from aligned microvessel and cardiomyocyte patches.Journal of tissue engineering and regenerative medicine · 2018Article
- Inosculation and perfusion of pre-vascularized tissue patches containing aligned human microvessels after myocardial infarction.Biomaterials · 2016Article
- The Effect of Sterilization Methods on the Structural and Chemical Properties of Fibrin Microthread Scaffolds.Macromolecular bioscience · 2016Article
- Functional Effects of a Tissue-Engineered Cardiac Patch From Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes in a Rat Infarct Model.Stem cells translational medicine · 2015Article
- Endothelial Network Formation Within Human Tissue-Engineered Skeletal Muscle.Tissue engineering. Part A · 2015Article
- Automated image analysis programs for the quantification of microvascular network characteristics.Methods (San Diego, Calif.) · 2015Review
- In vitro models of angiogenesis and vasculogenesis in fibrin gel.Experimental cell research · 2013Review
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
The development of engineered microvessels with clinically relevant characteristics is a critical step toward the creation of engineered myocardium. Alignment is one such characteristic that must be achieved, as it both mimics native capillary beds and provides natural inlet and outlet sides for perfusion. A second characteristic that is currently deficient is cross-sectional lumen density, typically under 100 lumens/mm²; the equivalent value for human myocardium is 2000 lumens/mm². Therefore, this study examined the effects of gel compaction and interstitial flow on microvessel alignment and lumen density. Strong microvessel alignment was achieved via mechanically constrained cell-induced fibrin gel compaction following vasculogenesis, and high lumen density (650 lumens/mm²) was achieved by the subsequent application of low levels of interstitial flow. Low interstitial flow also conferred microvessel barrier function.
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Registered trials
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