Evidence map›Paper›PMID 24083444›Full record

ArticleACS nano2013

Slow DNA transport through nanopores in hafnium oxide membranes.

Joseph Larkin, Robert Henley, David C Bell, Tzahi Cohen-Karni, Jacob K Rosenstein, Meni Wanunu

Abstract read
In one paragraph

Article in ACS nano, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers.

0numbers the graph read from it
0cells of the map it votes in
61citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

61 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Graphene Nanopore Fabrication and Applications.International journal of molecular sciences · 2025
    Review
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Review
  12. Review
  13. Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Dynamics of DNA Clogging in Hafnium Oxide Nanopores.The journal of physical chemistry. B · 2020
    Article

1 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Joseph Larkin *Departments of Physics and Chemistry/Chemical Biology, Northeastern University, Boston, Massachusetts 02115, United States.
Robert Henley *Departments of Physics and Chemistry/Chemical Biology, Northeastern University, Boston, Massachusetts 02115, United States.
David C BellSchool of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts 02138, United States.
Tzahi Cohen-KarniDavid H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States.
Jacob K RosensteinSchool of Engineering, Brown University, Providence, Rhode Island 02912, United States.
Meni WanunuDepartments of Physics and Chemistry/Chemical Biology, Northeastern University, Boston, Massachusetts 02115, United States.

Funding

Picogram-level DNA sequencing using Nanopores and Zero-Mode WaveguidesR21HG006873 · NHGRI · NORTHEASTERN UNIVERSITY · PI KORLACH, JONAS, WANUNU, MENI · 2012 to 2014
$812k
NHGRI NIH HHS R21 HG006873
6 · The paper itself

Abstract

We present a study of double- and single-stranded DNA transport through nanopores fabricated in ultrathin (2-7 nm thick) freestanding hafnium oxide (HfO2) membranes. The high chemical stability of ultrathin HfO2 enables long-lived experiments with <2 nm diameter pores that last several hours, in which we observe >50 000 DNA translocations with no detectable pore expansion. Mean DNA velocities are slower than velocities through comparable silicon nitride pores, providing evidence that HfO2 nanopores have favorable physicochemical interactions with nucleic acids that can be leveraged to slow down DNA in a nanopore.

Indexed as

NanoporesBiological TransportBiopolymersBiosensing TechniquesDNADNA, Single-StrandedHafniumMaterials TestingMembranes, ArtificialMicroscopy, Electron, ScanningMicroscopy, Electron, TransmissionNanotechnologyOxidesPolytetrafluoroethyleneSilicon CompoundsSurface PropertiesBiopolymersDNADNA, Single-StrandedHafniumhafnium oxideMembranes, ArtificialOxidesPolytetrafluoroethyleneSilicon Compoundssilicon nitride

Identifiers

PMID24083444
PMCPMC4729694

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.