ArticleJournal of pharmacy & bioallied sciences2013
In vitro antioxidant and H(+), K(+)-ATPase inhibition activities of Acalypha wilkesiana foliage extract.
Article in Journal of pharmacy & bioallied sciences, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Flavonoids from whole Plant ofPharmacognosy magazine · 2017Article
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsThe aim of this study was to evaluate the antioxidant activty and anti-acid property of Acalypha wilkesiana foliage extract. MATERIALS AND
methodsHot and cold aqueous extracts were prepared from healthy leaves of A. wilkesiana. Free radical scavenging activity and H(+), K(+)-ATPase inhibition activities of aqueous foliage extracts was screened by in vitro models. STATISTICAL ANALYSIS USED: All experiments were performed in triplicate and results are expressed as mean ± SEM.
resultsA. wilkesiana hot aqueous extract (AWHE) showed significant antioxidants and free radical scavenging activity. Further, AWHE has shown a potent H(+), K(+)-ATPase inhibitory activity (IC50: 51.5 ± 0.28 μg/ml) when compare to standard proton pump inhibitor omeprazole (56.2 ± 0.64 μg/ml); however, latter activity is equal to A. wilkesiana cold aqueous extract (AWCE). Quantitative analysis of AWHE has revealed more content of phenols and flavonoids; this is found to be the reason for good antioxidant activity over AWCE. Molecular docking was carried out against H(+), K(+)-ATPase enzyme crystal structure to validate the anti-acid activity of A. wilkesiana major phytochemicals.
conclusionsThe present study indicates that the constituents of AWHE and AWCE have good antacid and free radical scavenging activity.
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