ArticleJournal of human reproductive sciences2013
Micro-dissection testicular sperm extraction as an alternative for sperm acquisition in the most difficult cases of Azoospermia: Technique and preliminary results in India.
Article in Journal of human reproductive sciences, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 29 citations in OpenAlex.
- Prostate Cancer Treatments and Their Effects on Male Fertility: Mechanisms and Mitigation Strategies.Journal of personalized medicine · 2025Review
- Microdissection testicular sperm extraction (micro-TESE) in men with infertility due to nonobstructive azoospermia: summary of current literature.International urology and nephrology · 2021Review
- [Testicular sperm extraction in male infertility : Indications, success rates, practical implementation, and possible complications].Der Urologe. Ausg. A · 2021Review
- Reproductive Chances of Men with Azoospermia Due to Spermatogenic Dysfunction.Journal of clinical medicine · 2021Review
- Effect of testicular morphology on embryo development to the blastocyst stage after round spermatid injection.American journal of clinical and experimental urology · 2021Article
- Novel concepts in male factor infertility: clinical and laboratory perspectives.Journal of assisted reproduction and genetics · 2016Review
- Fourteen babies born after round spermatid injection into human oocytes.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Effect of hormonal manipulation using clomiphene citrate prior to microdissection testicular sperm retrieval.Urology annalsArticle
- Clinical management of infertile men with nonobstructive azoospermia.Asian journal of andrologyReview
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
contextNon-obstructive azoospermia (NOA) is an unfavorable prognostic condition for male infertility since spermatogenesis is disrupted. Sperm retrieval (SR) coupled with intracytoplasmic sperm injection (ICSI) is the only option for men with NOA who seek fertility. Among the SR techniques, microdissection testicular sperm extraction (micro-TESE) has been applied with encouraging results.
aimsWe describe how we implemented the micro-TESE procedure and present initial micro-TESE experience in a group of men with NOA and poor prognosis for SR. SETTINGS AND
designCase series of men with NOA treated in a tertiary healthcare center. MATERIALS AND
methodsAn Assisted Reproductive Technology (ART) facility was setup to perform SR using microsurgery. Fourteen men with NOA and previous failed retrievals or unfavorable histologic results underwent micro-TESE while their female partners received ovarian stimulation for oocyte pickup (OCP). Micro-TESE was performed the day prior to OCP and testicular sperm were used for sperm injections. We assessed retrieval rates and ICSI outcomes. STATISTICAL ANALYSIS: Outcomes of SR and ICSI were analyzed descriptively. Mann-Whitney and Fisher exact test were used to compare characteristics of men with successful and failed SR.
resultsThe success of micro-TESE was 50.0% with no major complications. A clear microscopic distinction between enlarged and collapsed seminiferous tubules was seen in 35.7% of the cases, and sperm were retrieved in all but one of these cases. Patients with successful and failed retrieval did not differ with respect to baseline characteristics, use of medical therapy, presence of varicocele, and testicular histology. Sperm injections resulted in normal fertilization and embryo cleavage of 64% and 75%, respectively. A total of five transfers with an average of 1.5 embryos resulted in a cumulative clinical pregnancy rate per ICSI cycle of 28.6%, with an implantation rate of 33.3%.
conclusionsWe were successful in integrating the micro-TESE procedures to the in vitro fertilization (IVF) laboratory. Our initial experience with micro-TESE applied to the most difficult cases of azoospermia is reassuring.
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