ArticleJournal of conservative dentistry : JCD2013
Differentiation of isolated and characterized human dental pulp stem cells and stem cells from human exfoliated deciduous teeth: An in vitro study.
Article in Journal of conservative dentistry : JCD, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- Chemically Defined Medium Enables GDNF-Driven Early Neuronal-like Phenotype of Human Dental Pulp Stem Cells.Cells · 2026Article
- Development of In Vitro Parkinson's Disease Model Mediated by MPP+ and α-Synuclein Using Wharton's Jelly Mesenchymal Stem Cells.CNS neuroscience & therapeutics · 2025Article
- Oscillatory fluid flow enhanced mineralization of human dental pulp cells.Frontiers in bioengineering and biotechnology · 2025Article
- Analogies and Differences Between Dental Stem Cells: Focus on Secretome in Combination with Scaffolds in Neurological Disorders.Stem cell reviews and reports · 2024Review
- Advanced Hydrogel systems for mandibular reconstruction.Bioactive materials · 2023Review
- Effects of mechanical force on proliferation and apoptosis of stem cells from human exfoliated deciduous teeth.Clinical oral investigations · 2022Article
- Increased strength in the Col-Tgel induces apoptosis in the human dental pulp stem cells: 3D culturing of human dental pulp stem cells at different strengths of collagen.Saudi journal of biological sciences · 2022Article
- The Potential Use of Mesenchymal Stem Cells and Their Derived Exosomes for Orthopedic Diseases Treatment.Stem cell reviews and reports · 2022Review
- The Effects of Cryogenic Storage on Human Dental Pulp Stem Cells.International journal of molecular sciences · 2021Article
- Comparison of stem cells from human exfoliated deciduous posterior teeth with varying levels of root resorption.Stem cell investigation · 2021Article
- Mesenchymal stem cells: amazing remedies for bone and cartilage defects.Stem cell research & therapy · 2020Review
- Review
- Multi-lineage differentiation and clinical application of stem cells from exfoliated deciduous teeth.Human cell · 2020Review
- Human Dental Pulp Stem Cells Exhibit Osteogenic Differentiation Potential.Open life sciences · 2020Article
- Towards a New Era in the Management of Large Periapical Lesion in Permanent Tooth Using Stemcells: A 2-Year Clinical Application Report.Journal of dentistry (Shiraz, Iran) · 2019Article
- Methylsulfonylmethane increases osteogenesis and regulates the mineralization of the matrix by transglutaminase 2 in SHED cells.PloS one · 2019Article
- A High-Resolution Proteomic Landscaping of Primary Human Dental Stem Cells: Identification of SHED- and PDLSC-Specific Biomarkers.International journal of molecular sciences · 2018Article
- Fibroblast growth factor-6 enhancesF1000Research · 2018Article
- Spreading, proliferation and differentiation of human dental pulp stem cells on chitosan scaffolds immobilized with RGD or fibronectin.Cytotechnology · 2017Article
- Allogeneic stem cells derived from human exfoliated deciduous teeth (SHED) for the management of periapical lesions in permanent teeth: Two case reports of a novel biologic alternative treatment.Journal of dental research, dental clinics, dental prospects · 2017Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
AIMS AND
objectivesIsolation, characterization and differentiation of dental pulp stem cells (DPSCs) and stem cells from exfoliated human deciduous teeth (SHED).
methodsThe pulp tissue was digested in collagenase and cultured in DMEM Dulbecco's Modified Eagle's Media). The stem cells were identified and isolated. Surface characterization of cells was done with flow cytometer using surface markers. An immuno cytochemistry analysis was done. Differentiation potential was analyzed using various differentiation markers.
resultsFlow cytometry analyses for various CD markers showed similar results for both DPSCs and SHED. The cells showed positive expression for pluripotent, ectodermal and mesodermal markers. Cells differentiated into osteoblasts and adipocytes.
conclusionThe study demonstrated that stem cells existed in deciduous and permanent pulp tissue. The stem cells present in pulp tissue can be isolated, cultivated and expanded in vitro. Both DPSCs and SHED show almost a similar expression pattern profile for variety of antigens tested.
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