ArticleIndian journal of clinical biochemistry : IJCB2012
Emerging Trend of Mutation Profile of rpoB Gene in MDR Tuberculosis, North India.
Article in Indian journal of clinical biochemistry : IJCB, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Engineered Biosensors for Diagnosing Multidrug Resistance in Microbial and Malignant Cells.Biosensors · 2023Review
- Novel mutations detected from drug resistant Mycobacterium tuberculosis isolated from North East of Thailand.World journal of microbiology & biotechnology · 2021Article
- Status of rpoB gene mutation associated with rifampicin-resistantAccess microbiology · 2021Article
- Drug-resistance inMedChemComm · 2019Review
- Mechanisms of fitness cost reduction for rifampicin-resistant strains with deletion or duplication mutations in rpoB.Scientific reports · 2018Article
- GeneChip analysis of resistant Mycobacterium tuberculosis with previously treated tuberculosis in Changchun.BMC infectious diseases · 2018Article
- Evaluation of Genotype MTBDRFrontiers in microbiology · 2018Article
- Direct Detection of Rifampin and Isoniazid Resistance in Sputum Samples from Tuberculosis Patients by High-Resolution Melt Curve Analysis.Journal of clinical microbiology · 2017Article
- Direct detection of Mycobacterium tuberculosis rifampin resistance in bio-safe stained sputum smears.PloS one · 2017Article
- Alarmingly High Segregation Frequencies of Quinolone Resistance Alleles within Human and Animal Microbiomes Are Not Explained by Direct Clinical Antibiotic Exposure.Genome biology and evolution · 2015Article
- Rapid Molecular Detection of Multidrug-Resistant Tuberculosis by PCR-Nucleic Acid Lateral Flow Immunoassay.PloS one · 2015Article
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5 authors.
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Abstract
The present study was conducted on North Indian population to observe rpoB gene mutation profile in multidrug resistant Mycobacterium tuberculosis. This was an observational study. 30 cases of MDR-TB proven by culture and drug sensitivity were selected. DNA sequencing of 81 bp (codon 507-533) long RRDR of Mycobacterium tuberculosis was done to detect the sites of mutation. Out of 30 cases, 24 showed a single mutation in the RRDR region of rpoB gene in which 16 (53.33 %) showed mutation in codon 531(TCG→TTG), 5 cases (16.66 %) showed mutation in codon 526(CAC→TAC), mutation in codon 516(GAC→GTC, AAC) was present in 3 cases (10 %). It was also observed that mutation in more than one codon was present in 4 cases (13.33 %), which included deletion at codon 509(AGC→-GC), mutation at 513(CAA→CTA), 516, 526, 529(CGA→CTA) and 531. No mutation was detected in RRDR in 2 cases (6.66 %). Our finding of 13.33 % cases with multiple sites of mutation in RRDR region is in contrast to earlier studies done in North India which showed single mutation detected in RRDR of rpoB gene that highlights the emerging change in the trend of mutation profile of rpoB gene in rifampicin resistant Mycobacterium tuberculosis.
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