Evidence map›Paper›PMID 24082313›Full record

ArticleSleep2013

Midlife sleep characteristics associated with late life cognitive function.

Jyri J Virta, Kauko Heikkilä, Markus Perola, Markku Koskenvuo, Ismo Räihä, Juha O Rinne, Jaakko Kaprio

Registry-linked trialAbstract readTwin Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Sleep, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05561829 (Determination of Optimal Sleep Treatment Elements), which is not on this map. Cited by 88 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
88citing papers in PubMed, 8 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05561829 nacompletednot on this mapstarted 2022, after this paper: background citation

Determination of Optimal Sleep Treatment Elements (The DOSE Project)

TypeinterventionalSponsorUniversity of AarhusRan2022 to 2024Enrolled489ConditionsInsomnia ChronicArmsSleep Optimization, Stimulus Control Therapy, Relaxation Training, Cognitive Therapy, Sleep Hygiene Education
3 · Its place in the literature

Who cites it

88 citing papers in PubMed, 8 syntheses or guidelines pooled it.

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  14. The effect of sleep disturbances on the incidence of dementia for varying lag times.The journal of prevention of Alzheimer's disease · 2025
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28 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jyri J VirtaHjelt Institute, Department of Public Health, University of Helsinki, Finland ; Turku PET Centre, University of Turku and Turku University Hospital, Turku, Finland.
Kauko Heikkilä
Markus Perola
Markku Koskenvuo
Ismo Räihä
Juha O Rinne
Jaakko Kaprio

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

STUDY

objectivesPrevious studies with limited follow-up times have suggested that sleep-related traits are associated with an increased risk of incident dementia or cognitive decline. We investigated the association between midlife sleep characteristics and late life cognitive function.

designA follow-up study with a median follow-up time of 22.5 (range 15.8-25.7) years assessing the association between midlife sleep characteristics and later cognitive function.

settingQuestionnaire data from 1981 were used in the assessment of sleep characteristics, use of hypnotics, and covariates at baseline. Between 1999 and 2007, participants were assigned a linear cognitive score with a maximum score of 51 based on a telephone interview (mean score 38.3, SD 6.1). Linear regression analyses were controlled for age, sex, education, ApoE genotype, and follow-up time.

participants2,336 members of the Finnish Twin cohort who were at least 65 years of age.

interventionsN/A. MEASUREMENTS AND

resultsBaseline short (< 7 h/day) and long (> 8 h/day) sleepers had lower cognitive scores than participants sleeping 7-8 h/ day (β = -0.84, P = 0.014 and β = -1.66, P < 0.001, respectively). As compared to good sleep quality, poor or rather poor sleep quality was associated with a lower cognitive score (β = -1.00, P = 0.011). Also, the use of hypnotics ≥ 60 days per year was associated with poorer cognitive function (β = -1.92, P = 0.002).

conclusionsThis is the first study indicating that midlife sleep length, sleep quality, and use of hypnotics are associated with late life cognitive function. Further confirmation is needed, but sleep-related characteristics may emerge as new risk factors for cognitive impairment.

Indexed as

AgedAge FactorsApolipoproteins ECognitionCognitive DysfunctionDementiaDiseases in TwinsFemaleFollow-Up StudiesGenotypeHumansHypnotics and SedativesInterviews as TopicMaleMiddle AgedNeuropsychological TestsApolipoproteins EHypnotics and SedativesCognitioncohort studieshypnotics and sedativesrisk factorssleep

Identifiers

PMID24082313
PMCPMC3773203

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.