ArticleSleep2013
Obstructive sleep apnea is associated with preserved bone mineral density in healthy elderly subjects.
Article in Sleep, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 3 of them syntheses that pooled it.
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Who cites it
40 citing papers in PubMed, 3 syntheses or guidelines pooled it, 69 citations in OpenAlex.
- Relationship between obstructive sleep apnea-hypopnea syndrome and osteoporosis adults: A systematic review and meta-analysis.Frontiers in endocrinology · 2022Pooled it
- Can Hypoxic Conditioning Improve Bone Metabolism? A Systematic Review.International journal of environmental research and public health · 2019Pooled it
- Association between sleep apnea and low bone mass in adults: a systematic review and meta-analysis.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2017Pooled it
- Bone mineral density and changes in bone metabolism in patients with obstructive sleep apnea syndrome.Journal of bone and mineral metabolism · 2016Trial
- Article
- Objectively measured sleep parameters and bone health: results from the Human Phenotype Project (HPP) cohort.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2026Article
- Sleep-Disordered Breathing and Decreased Bone Mineral Density: Masking Effects of Body Mass Index.Obesity facts · 2026Article
- Age-dependent association between obstructive sleep apnea and self-reported history of fractures: a community-based study.BMC public health · 2025Article
- High prevalence of vertebral fractures associated with apnea-hypopnea index in patients with recent diagnosis of obstructive sleep apnea.BMC musculoskeletal disorders · 2025Article
- Impact of the visceral adipose tissue on bone quality in patients with untreated mild-to-severe obstructive sleep apnea.Journal of sleep research · 2025Article
- Exploring the Intersection of Diabetes and Musculoskeletal Health : Diabetes and Musculoskeletal Health.Galen medical journal · 2025Review
- Causal evidence of the relationship between polycystic ovary syndrome and obstructive sleep apnea in European and East Asian populations: a two-sample Mendelian randomization study.Journal of thoracic disease · 2024Article
- Association of obstructive sleep apnea with bone metabolism in older adults: a hospital-based study.BMC musculoskeletal disorders · 2024Article
- Early bone loss in patients with obstructive sleep apnea: a cross-sectional study.BMC pulmonary medicine · 2024Article
- Association between obstructive sleep apnea and low bone mass in adults: a systematic review and meta-analysis.Sleep and biological rhythms · 2024Article
- Body mass index mediates the association between plasma lipid concentrations and the prevalence of obstructive sleep apnea among US adults: a cross-sectional study.Frontiers in cardiovascular medicine · 2024Article
- Bone mineral density alteration in obstructive sleep apnea by derived computed tomography screening.Scientific reports · 2022Article
- Molecular Mechanisms Involved in Hypoxia-Induced Alterations in Bone Remodeling.International journal of molecular sciences · 2022Review
- Lumbar spine abnormalities in patients with obstructive sleep apnoea.Scientific reports · 2021Article
- Sleep disruptions and bone health: what do we know so far?Current opinion in endocrinology, diabetes, and obesity · 2021Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
STUDY
objectivesChronic intermittent hypoxia (IH) acts as a stimulator of mesenchymal stem cell (MSC) mobilization, intensifying osteoblast formation in animal models. The recurrence of apnea and oxygen desaturation in obstructive sleep apnea (OSA) may mimic experimental models of IH. We hypothesized that in elderly with OSA, apnea-related IH may mobilize MSCs and thereby prevent the age-related decline in osteogenesis. This study explored the relationship between OSA and bone mineral density (BMD), and the effect of IH on BMD, in a large sample of elderly subjects.
participantsThere were 833 volunteers age 68.6 ± 0.8 y (59% women).
interventionEach participant underwent evaluation of BMD at lumbar spine and femoral sites by dual-energy x-ray absorptiometry (DEXA) as well as clinical and polygraphic examinations. OSA was diagnosed on the basis of an apnea-hypopnea index (AHI) ≥ 15. MEASUREMENTS AND
resultsThere were 55% of the participants who presented with OSA, and these subjects were predominantly male and overweight. Compared with subjects without OSA, those with OSA had a higher femoral and spinal BMD (P < 0.001). Body mass index (BMI), AHI, and oxygen desaturation index (ODI) (P < 0.01) were significantly related to BMD. After adjustment for sex, BMI, metabolic values, and hypertension, multiple regression analysis showed a significant association between femoral and lumbar T scores and both daily energy expenditure (P < 0.001) and ODI (P = 0.007).
conclusionsIn elderly subjects, the presence of obstructive sleep apnea is associated with higher bone mineral density, with oxygen desaturation index being a significant determinant of bone metabolism. These results suggest that apnea-related intermittent hypoxia may stimulate the bone remodeling process in older population. CLINICAL
trial registrationNCT 00759304 and NCT 00766584.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.