Evidence map›Paper›PMID 24082148›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2013

Significance of endangered and threatened plant natural products in the control of human disease.

Mohamed Ali Ibrahim, MinKyun Na, Joonseok Oh, Raymond F Schinazi, Tami R McBrayer, Tony Whitaker, Robert J Doerksen, David J Newman, Louis G Zachos, Mark T Hamann

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 84 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Diterpenoid Alkaloids Isolated fromMolecules (Basel, Switzerland) · 2022
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. An analysis of the spongeFrontiers in Marine Science · 2014
    Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 3 countries.

Mohamed Ali IbrahimDepartments of Pharmacognosy, Medicinal Chemistry, Geology and Geological Engineering, National Center for Natural Products Research, and Departments of Pharmacology, Chemistry, and Biochemistry, School of Pharmacy, The University of Mississippi, University, MS 38677.
MinKyun Na
Joonseok Oh
Raymond F Schinazi
Tami R McBrayer
Tony Whitaker
Robert J Doerksen
David J Newman
Louis G Zachos
Mark T Hamann
University of Mississippi · USVifor Pharma (United States) · USChungnam National University · KRInstitute of Medicinal Plant Development · CNNational Institutes of Health · USVeterans Health Administration · US

Funding

Virology and Molecular Biomarkers CoreP30AI050409 · NIAID · EMORY UNIVERSITY · PI Carlos del Rio · 2002 to 2026
$74.0M
Natural Product HCV Drugs from Rare Plant-Microbe InteractionsR01AT007318 · NCCIH · UNIVERSITY OF MISSISSIPPI · PI HAMANN, MARK T · 2012 to 2016
$1.6M
NCCIH NIH HHS R01 AT007318NCCIH NIH HHS R01-AT-007318NCI NIH HHS CO6-RR-145503NIAID NIH HHS 2P30-AI-050409NIAID NIH HHS P30 AI050409
6 · The paper itself

Abstract

One in five of the world's plant species is threatened with extinction according to the 2010 first global analysis of extinction risk. Tilman et al. predicted a massive ecological change to terrestrial plants within the next 50-100 y, accompanied by an increase in the number of global plant species facing extinction [Tilman D, et al. (2001) Proc Natl Acad Sci USA 98(10):5433-5440]. Most of the drug-producing plant families contain endangered species never previously studied for their utility to human health, which strongly validates the need to prioritize protection and assessment of these fragile and endangered groups [Zhu F, et al. (2011) Proc Natl Acad Sci USA 108(31):12943-12948]. With little prior attention given to endangered and rare plant species, this report provides strong justification for conservation of the rare plant Diplostephium rhododendroides Hieron., as well as other potential drug-producing endangered species in this and other groups.

Indexed as

Endangered SpeciesAsteraceaeDiabetes MellitusHumansPhytotherapyPlants, Medicinaldiabetes mellitusendangered plantshepatitis C virus

Identifiers

PMID24082148
PMCPMC3801070
OpenAlexW2055367007

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.