ArticleProceedings of the National Academy of Sciences of the United States of America2013
Hijacking of leguminous nodulation signaling by the rhizobial type III secretion system.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 120 papers.
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Who cites it
120 citing papers in PubMed, 265 citations in OpenAlex.
- Type III secretion system diversity in the Pseudomonas fluorescens species complex.The New phytologist · 2026Article
- Review
- Coordination of PTI and ETI in legume-rhizobium mutualism.aBIOTECH · 2026Review
- Rhizobial Nod factors modulate reactive oxygen species, jasmonates, and pattern-recognizing receptors to suppress immune response.Plant molecular biology · 2026Article
- Bradyrhizobium dasycarpae sp. nov. a novel rhizobial species lacking canonical nod genes, isolated from the Moroccan endemic legume Retama dasycarpa.Antonie van Leeuwenhoek · 2026Article
- Advances in rhizobial technology: driving sustainable agriculture in the 21 st century.Archives of microbiology · 2026Review
- Systemic proteome remodeling in soybean during early nodulation: distinct responses in roots and leaves.Frontiers in plant science · 2026Article
- Effects of Soil Moisture Content and Rj Genotype Differences on Soybean Productivity and Soybean-nodulating Bradyrhizobial Occupancy.Microbes and environments · 2026Article
- Unveiling the diversity and mechanisms of plant growth-promoting bacteria in orchids: a comprehensive review.Frontiers in microbiology · 2026Review
- Article
- The rhizobial type III effectors ErnA and Sup3 hijack the SUMOylation pathway to trigger nodule formation in Aeschynomene species.The New phytologist · 2025Article
- Putative type III effector SkP48 of Bradyrhizobium sp. DOA9 encoding a SUMO protease blocks nodulation in Vigna radiata.Scientific reports · 2025Article
- Enacting partner specificity in legume-rhizobia symbioses.aBIOTECH · 2025Review
- Type III Secretion System-Mediated Induction of Systemic Resistance byPlants (Basel, Switzerland) · 2025Article
- Beyond pathogenicity: the immunomodulatory role of the type III secretion system in beneficial plant-microbe interactions.Open biology · 2025Review
- Regulation of Root Nodule Symbiosis by Soybean Rj Genotypes and Rhizobial Effectors.Microbes and environments · 2025Review
- Atypical rhizobia trigger nodulation and pathogenesis on the same legume hosts.Nature communications · 2024Article
- NopP2 effector of Bradyrhizobium elkanii USDA61 is a determinant of nodulation in Vigna radiata cultivars.Scientific reports · 2024Article
- Transcriptomes of soybean roots and nodules inoculated with Sinorhizobium fredii with NopP and NopI variants.Scientific data · 2024Article
- Comparative genomic and transcriptomic analyses provide new insight into symbiotic host specificity.iScience · 2024Article
60 more citing papers are in PubMed but not listed here.
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Authors and funding
4 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Root-nodule symbiosis between leguminous plants and nitrogen-fixing bacteria (rhizobia) involves molecular communication between the two partners. Key components for the establishment of symbiosis are rhizobium-derived lipochitooligosaccharides (Nod factors; NFs) and their leguminous receptors (NFRs) that initiate nodule development and bacterial entry. Here we demonstrate that the soybean microsymbiont Bradyrhizobium elkanii uses the type III secretion system (T3SS), which is known for its delivery of virulence factors by pathogenic bacteria, to promote symbiosis. Intriguingly, wild-type B. elkanii, but not the T3SS-deficient mutant, was able to form nitrogen-fixing nodules on soybean nfr mutant En1282. Furthermore, even the NF-deficient B. elkanii mutant induced nodules unless T3SS genes were mutated. Transcriptional analysis revealed that expression of the soybean nodulation-specific genes ENOD40 and NIN was increased in the roots of En1282 inoculated with B. elkanii but not with its T3SS mutant, suggesting that T3SS activates host nodulation signaling by bypassing NF recognition. Root-hair curling and infection threads were not observed in the roots of En1282 inoculated with B. elkanii, indicating that T3SS is involved in crack entry or intercellular infection. These findings suggest that B. elkanii has adopted a pathogenic system for activating host symbiosis signaling to promote its infection.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.