ArticleProceedings of the National Academy of Sciences of the United States of America2013
A cytochrome P450 regulates a domestication trait in cultivated tomato.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 144 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
144 citing papers in PubMed, 1 synthesis or guideline pooled it, 337 citations in OpenAlex.
- Advancing crop improvement through GWAS and beyond in mung bean.Frontiers in plant science · 2024Pooled it
- Multi-variant GWAS and genomic prediction dissect the genetic architecture underlying tomato fruit weight.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2026Article
- Natural variation in SlGRF10 reveals a role in regulating tomato fruit weight.Plant physiology · 2026Article
- Establishment of a Genetic Transformation System forPlants (Basel, Switzerland) · 2026Article
- Reproductive Diversity in Cultivated Tomato (Plants (Basel, Switzerland) · 2026Article
- Fruit weight regulation by a paralog of Cell Size Regulator (CSR) in tomato and other crops.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2026Article
- Association mapping of tomato fruit quality for weight, firmness, brix, and color using GWAS.BMC plant biology · 2025Article
- Pangenome identification and functional characterization of AHL genes in wheat (Triticum aestivum L.) reveal the role of TaAHL67 in grain weight regulation.BMC plant biology · 2025Article
- Transcriptional control of tomato fruit development and ripening.Journal of experimental botany · 2025Review
- What metabolomics has taught us about tomato fruit ripening and quality.Journal of experimental botany · 2025Review
- Review
- Co-Selection of Low Cadmium Accumulation and High Yield During Tomato Improvement.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Genome-wide meta-QTL approach identifies consensus loci associated with agriculturally important tomato fruit traits.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2025Article
- Review
- Identification of quantitative trait loci and candidate genes underlying kernel traits of wheat (Triticum aestivum L.) in response to drought stress.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2025Article
- Genetic Mapping of a QTL Controlling Fruit Size in Melon (Plants (Basel, Switzerland) · 2025Article
- Developmental rewiring of the NGAL/CUC/KLU network associated with pleiotropic roles of NGAL genes.The Plant journal : for cell and molecular biology · 2025Article
- A SlRBP1-Horticulture research · 2025Article
- Genome-Wide Identification of thePlants (Basel, Switzerland) · 2025Article
- Cytochromes P450 evolution in the plant terrestrialization context.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Review
84 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Domestication of crop plants had effects on human lifestyle and agriculture. However, little is known about the underlying molecular mechanisms accompanying the changes in fruit appearance as a consequence of selection by early farmers. We report the fine mapping and cloning of a tomato (Solanum lycopersicum) fruit mass gene encoding the ortholog of KLUH, SlKLUH, a P450 enzyme of the CYP78A subfamily. The increase in fruit mass is predominantly the result of enlarged pericarp and septum tissues caused by increased cell number in the large fruited lines. SlKLUH also modulates plant architecture by regulating number and length of the side shoots, and ripening time, and these effects are particularly strong in plants that transgenically down-regulate SlKLUH expression carrying fruits of a dramatically reduced mass. Association mapping followed by segregation analyses revealed that a single nucleotide polymorphism in the promoter of the gene is highly associated with fruit mass. This single polymorphism may potentially underlie a regulatory mutation resulting in increased SlKLUH expression concomitant with increased fruit mass. Our findings suggest that the allele giving rise to large fruit arose in the early domesticates of tomato and becoming progressively more abundant upon further selections. We also detected association of fruit weight with CaKLUH in chile pepper (Capsicum annuum) suggesting that selection of the orthologous gene may have occurred independently in a separate domestication event. Altogether, our findings shed light on the molecular basis of fruit mass, a key domestication trait in tomato and other fruit and vegetable crops.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.