Evidence map›Paper›PMID 24082105›Full record

Trial reportProceedings of the National Academy of Sciences of the United States of America2013

Like cognitive function, decision making across the life span shows profound age-related changes.

Agnieszka Tymula, Lior A Rosenberg Belmaker, Lital Ruderman, Paul W Glimcher, Ifat Levy

Erratum issuedOpen access · bronzeAbstract readClinical TrialMulticenter Study
In one paragraph

Trial report in Proceedings of the National Academy of Sciences of the United States of America, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 108 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
108citing papers in PubMed, 3 pooled it
11.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

108 citing papers in PubMed, 3 syntheses or guidelines pooled it, 289 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Propranolol reduces reference-dependence in intertemporal choice.Social cognitive and affective neuroscience · 2017
    Trial
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  9. Positive risk taking across the world.Journal of research on adolescence : the official journal of the Society for Research on Adolescence · 2025
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48 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Agnieszka TymulaSchool of Economics, University of Sydney, Sydney, NSW 2006, Australia.
Lior A Rosenberg Belmaker
Lital Ruderman
Paul W Glimcher
Ifat Levy
New York University · USUniversity of Sydney · AUYale University · US

Funding

Cognitive Bases of Risk-taking Over the Lifespan: Psychophysics & Brain ImagingR01AG033406 · NIA · YALE UNIVERSITY · PI GLIMCHER, PAUL W, LEVY, IFAT · 2010 to 2014
$1.6M
NIA NIH HHS R01 5R01AG033406NIA NIH HHS R01 AG033406
6 · The paper itself

Abstract

It has long been known that human cognitive function improves through young adulthood and then declines across the later life span. Here we examined how decision-making function changes across the life span by measuring risk and ambiguity attitudes in the gain and loss domains, as well as choice consistency, in an urban cohort ranging in age from 12 to 90 y. We identified several important age-related patterns in decision making under uncertainty: First, we found that healthy elders between the ages of 65 and 90 were strikingly inconsistent in their choices compared with younger subjects. Just as elders show profound declines in cognitive function, they also show profound declines in choice rationality compared with their younger peers. Second, we found that the widely documented phenomenon of ambiguity aversion is specific to the gain domain and does not occur in the loss domain, except for a slight effect in older adults. Finally, extending an earlier report by our group, we found that risk attitudes across the life span show an inverted U-shaped function; both elders and adolescents are more risk-averse than their midlife counterparts. Taken together, these characterizations of decision-making function across the life span in this urban cohort strengthen the conclusions of previous reports suggesting a profound impact of aging on cognitive function in this domain.

Indexed as

AdolescentAdultAgedAged, 80 and overAgingChildCognitionCohort StudiesDecision MakingFemaleHumansMaleMiddle AgedUrban Population

Identifiers

PMID24082105
PMCPMC3801020
OpenAlexW2031848389

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.