ArticleProceedings of the National Academy of Sciences of the United States of America2013
Heme impairs the ball-and-chain inactivation of potassium channels.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed.
- Heme as a versatile signaling molecule: Coordinating mitochondrial metabolism with global cellular responses.The Journal of biological chemistry · 2026Review
- Exceptionally selective voltage-sensor trapping of NaScientific reports · 2026Article
- Cytochrome C-like Domain Within the Human BK Channel.International journal of molecular sciences · 2025Article
- Heme regulates protein interactions and phosphorylation of BACH2 intrinsically disordered region in humoral response.iScience · 2025Article
- The Neural Palette of Heme: Altered Heme Homeostasis Underlies Defective Neurotransmission, Increased Oxidative Stress, and Disease Pathogenesis.Antioxidants (Basel, Switzerland) · 2024Review
- Impact of Phosphorylation at Various Sites on the Active Pocket of Human Ferrochelatase: Insights from Molecular Dynamics Simulations.International journal of molecular sciences · 2024Article
- Interaction of Some Asymmetrical Porphyrins with U937 Cell Membranes-In Vitro and In Silico Studies.Molecules (Basel, Switzerland) · 2023Article
- Extracellular hemin is a reverse use-dependent gating modifier of cardiac voltage-gated NaBiological chemistry · 2022Article
- External Hemin as an Inhibitor of Mitochondrial Large-Conductance Calcium-Activated Potassium Channel Activity.International journal of molecular sciences · 2022Article
- Intracellular hemin is a potent inhibitor of the voltage-gated potassium channel Kv10.1.Scientific reports · 2022Article
- Review
- Heme controls the structural rearrangement of its sensor protein mediating the hemolytic bacterial survival.Communications biology · 2021Article
- Intracellular activation of full-length human TREK-1 channel by hypoxia, high lactate, and low pH denotes polymodal integration by ischemic factors.Pflugers Archiv : European journal of physiology · 2021Article
- Carbon Monoxide (CO), Nitric Oxide, and Hydrogen Sulfide Signaling During Acute CO Poisoning.Frontiers in pharmacology · 2021Review
- MFSD7C switches mitochondrial ATP synthesis to thermogenesis in response to heme.Nature communications · 2020Article
- Discovery of a heme-binding domain in a neuronal voltage-gated potassium channel.The Journal of biological chemistry · 2020Article
- A new world of heme function.Pflugers Archiv : European journal of physiology · 2020Article
- Impact of intracellular hemin on N-type inactivation of voltage-gated KPflugers Archiv : European journal of physiology · 2020Article
- Altered gating of KeLife · 2019Article
- Modulation of KPflugers Archiv : European journal of physiology · 2019Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
Fine-tuned regulation of K(+) channel inactivation enables excitable cells to adjust action potential firing. Fast inactivation present in some K(+) channels is mediated by the distal N-terminal structure (ball) occluding the ion permeation pathway. Here we show that Kv1.4 K(+) channels are potently regulated by intracellular free heme; heme binds to the N-terminal inactivation domain and thereby impairs the inactivation process, thus enhancing the K(+) current with an apparent EC50 value of ∼20 nM. Functional studies on channel mutants and structural investigations on recombinant inactivation ball domain peptides encompassing the first 61 residues of Kv1.4 revealed a heme-responsive binding motif involving Cys13:His16 and a secondary histidine at position 35. Heme binding to the N-terminal inactivation domain induces a conformational constraint that prevents it from reaching its receptor site at the vestibule of the channel pore.
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