Evidence map›Paper›PMID 24082038›Full record

SynthesisHuman reproduction update

Guidelines for the design, analysis and interpretation of 'omics' data: focus on human endometrium.

Signe Altmäe, Francisco J Esteban, Anneli Stavreus-Evers, Carlos Simón, Linda Giudice, Bruce A Lessey, Jose A Horcajadas, Nick S Macklon, Thomas D'Hooghe, Cristina Campoy and 3 more

Abstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Human reproduction update. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
58citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

58 citing papers in PubMed, 5 syntheses or guidelines pooled it.

  1. Pooled it
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  7. Observational
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  17. Identification of a rare copy number polymorphic gain at 3q12.2 with candidate genes for familial endometriosis.Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Signe AltmäeCompetence Centre on Reproductive Medicine and Biology, Tartu, Estonia.
Francisco J Esteban
Anneli Stavreus-Evers
Carlos Simón
Linda Giudice
Bruce A Lessey
Jose A Horcajadas
Nick S Macklon
Thomas D'Hooghe
Cristina Campoy
Bart C Fauser
Lois A Salamonsen
Andres Salumets

Funding

Progesterone Action in the Endometrium of Women with EndometriosisR01HD067721 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI YOUNG, STEVEN L · 2011 to 2015
$3.1M
NICHD NIH HHS R01 HD067721
6 · The paper itself

Abstract

background'Omics' high-throughput analyses, including genomics, epigenomics, transcriptomics, proteomics and metabolomics, are widely applied in human endometrial studies. Analysis of endometrial transcriptome patterns in physiological and pathophysiological conditions has been to date the most commonly applied 'omics' technique in human endometrium. As the technologies improve, proteomics holds the next big promise for this field. The 'omics' technologies have undoubtedly advanced our knowledge of human endometrium in relation to fertility and different diseases. Nevertheless, the challenges arising from the vast amount of data generated and the broad variation of 'omics' profiling according to different environments and stimuli make it difficult to assess the validity, reproducibility and interpretation of such 'omics' data. With the expansion of 'omics' analyses in the study of the endometrium, there is a growing need to develop guidelines for the design of studies, and the analysis and interpretation of 'omics' data.

methodsSystematic review of the literature in PubMed, and references from relevant articles were investigated up to March 2013.

resultsThe current review aims to provide guidelines for future 'omics' studies on human endometrium, together with a summary of the status and trends, promise and shortcomings in the high-throughput technologies. In addition, the approaches presented here can be adapted to other areas of high-throughput 'omics' studies.

conclusionA highly rigorous approach to future studies, based on the guidelines provided here, is a prerequisite for obtaining data on biological systems which can be shared among researchers worldwide and will ultimately be of clinical benefit.

Indexed as

Guidelines as TopicEmbryo ImplantationEndometriumFemaleGenomicsHigh-Throughput Nucleotide SequencingHumansMetabolomicsSystems Biologyendometriumepigenomicsgenomicsmetabolomicsproteomics

Identifiers

PMID24082038
PMCPMC3845681

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.