ArticleThe Plant cell2013
The C2H2 transcription factor regulator of symbiosome differentiation represses transcription of the secretory pathway gene VAMP721a and promotes symbiosome development in Medicago truncatula.
Article in The Plant cell, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 1 of them a synthesis that pooled it.
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Who cites it
51 citing papers in PubMed, 1 synthesis or guideline pooled it, 113 citations in OpenAlex.
- Pooled it
- Decoding the landscape of cell-type-specific co-expressed transcription factors in soybean.Nature plants · 2026Article
- MtGRF8 interacts with MtSymCRK and prevents early bacteroid death during Medicago - Sinorhizobium symbiosis.The New phytologist · 2026Article
- Molecular cartography of root nodule organogenesis: insights into the role of transcription factors.Plant molecular biology · 2026Review
- Organized peripheral vascular strand development in nodules is controlled by a bHLH/HLH heterodimer.The New phytologist · 2026Article
- ESN3, a nodule-specific small peptide essential for symbiotic nitrogen fixation in Medicago truncatula.The New phytologist · 2026Article
- Coordination of PTI and ETI in legume-rhizobium mutualism.aBIOTECH · 2026Review
- Rhizobial Nod factors modulate reactive oxygen species, jasmonates, and pattern-recognizing receptors to suppress immune response.Plant molecular biology · 2026Article
- Nodule-Microbiome Dynamics: Deciphering the Complexities of Nodule Symbiosis and the Root Microbiome.International journal of molecular sciences · 2026Review
- Diverse triggers, common outcome: Senescence in Fix⁻ Medicago truncatula nodules.Plant physiology · 2025Article
- Defense and senescence interplay in legume nodules.Plant communications · 2024Review
- OROSOMUCOID PROTEIN 1 regulation of sphingolipid synthesis is required for nodulation in Aeschynomene evenia.Plant physiology · 2024Article
- Differential symbiotic compatibilities between rhizobium strains and cultivated and wild soybeans revealed by anatomical and transcriptome analyses.Frontiers in plant science · 2024Article
- Effects of Elevated Temperature onInternational journal of molecular sciences · 2023Article
- Dual RNA-Seq Analysis Pinpoints a Balanced Regulation between Symbiosis and Immunity inInternational journal of molecular sciences · 2023Article
- Comparative phylotranscriptomics reveals ancestral and derived root nodule symbiosis programmes.Nature plants · 2023Article
- Exogenously Applied Cytokinin Altered the Bacterial Release and Subsequent Stages of Nodule Development in PeaPlants (Basel, Switzerland) · 2023Article
- Insight into the control of nodule immunity and senescence during Medicago truncatula symbiosis.Plant physiology · 2023Article
- Comprehensive Analysis ofGenes · 2022Article
- A legume kinesin controls vacuole morphogenesis for rhizobia endosymbiosis.Nature plants · 2022Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Transcription factors (TFs) are thought to regulate many aspects of nodule and symbiosis development in legumes, although few TFs have been characterized functionally. Here, we describe regulator of symbiosome differentiation (RSD) of Medicago truncatula, a member of the Cysteine-2/Histidine-2 (C2H2) family of plant TFs that is required for normal symbiosome differentiation during nodule development. RSD is expressed in a nodule-specific manner, with maximal transcript levels in the bacterial invasion zone. A tobacco (Nicotiana tabacum) retrotransposon (Tnt1) insertion rsd mutant produced nodules that were unable to fix nitrogen and that contained incompletely differentiated symbiosomes and bacteroids. RSD protein was localized to the nucleus, consistent with a role of the protein in transcriptional regulation. RSD acted as a transcriptional repressor in a heterologous yeast assay. Transcriptome analysis of an rsd mutant identified 11 genes as potential targets of RSD repression. RSD interacted physically with the promoter of one of these genes, VAMP721a, which encodes vesicle-associated membrane protein 721a. Thus, RSD may influence symbiosome development in part by repressing transcription of VAMP721a and modifying vesicle trafficking in nodule cells. This establishes RSD as a TF implicated directly in symbiosome and bacteroid differentiation and a transcriptional regulator of secretory pathway genes in plants.
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