ArticlePsychopharmacology2014
Sex-influence of nicotine and nitric oxide on motor coordination and anxiety-related neurophysiological responses.
Article in Psychopharmacology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 19 citations in OpenAlex.
- Four-parameter analysis in modified Rotarod test for detecting minor motor deficits in mice.BMC biology · 2023Article
- The eNOS isoform exhibits increased expression and activation in the main olfactory bulb of nNOS knock-out mice.Frontiers in cellular neuroscience · 2023Article
- Nicotine Facilitates Facial Stimulation-Evoked Mossy Fiber-Granule Cell Long-Term PotentiationFrontiers in cellular neuroscience · 2022Article
- Sleep loss mediates the effect of stress on nitrergic signaling in female mice.Neuroscience letters · 2021Article
- Cytoskeleton stability is essential for the integrity of the cerebellum and its motor- and affective-related behaviors.Scientific reports · 2018Article
- Salivary Nitric Oxide, a Biomarker for Stress and Anxiety?Psychiatry investigation · 2016Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
rationaleNitric oxide (NO) is a messenger synthesized in both the neuronal and glial populations by nitric oxide synthase type 1 (NOS1). Nicotine regulates NO production in a sex-dependent manner, both molecules being involved in motor function.
objectiveThe present study evaluates sex differences in motor coordination, general movement, and anxiety-related responses resulting from both constant and continuous nicotine treatment and the genetic depletion of NOS1 activity.
methodsMale and female mice were analyzed with the open-field and the rotarod tests. To understand the role of NO, knockout mice for NOS1 (NOS1-/-) were analyzed. Nicotine was administered continuously at a dose of 24 mg/kg/day via osmotic mini-pumps over 14 days because the behavioral effects elicited are similar to those observed with discontinuous administration.
resultsData analyses revealed noteworthy sex differences derived from NOS1 depletion. Control NOS1-/- males exhibited an exacerbated anxiety-related response in relation to control NOS1-/- females and control wild-type (WT) males; these differences disappeared in the nicotine-administered NOS1-/- males. Additionally, nicotine administration differentially affected the horizontal movements of NOS1-/- females with respect to WT animals. NO depletion affected male but not female motor coordination improvement along the test days. However, the drug affected female motor coordination only at the end of the administration period.
conclusionsWe show for the first time that NO affects motor and anxiety behaviors in a sex-dependent manner. Moreover, the behavioral effects of constant nicotine administration are dimorphic and dependent on NO production.
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