ArticleLipids2014
Dietary linoleic acid elevates the endocannabinoids 2-AG and anandamide and promotes weight gain in mice fed a low fat diet.
Article in Lipids, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
41 citing papers in PubMed, 1 synthesis or guideline pooled it, 94 citations in OpenAlex.
- An individual participant data meta-analysis on metabolomics profiles for obesity and insulin resistance in European children.Scientific reports · 2019Pooled it
- Modulation of plasma N-acylethanolamine levels and physiological parameters by dietary fatty acid composition in humans.Journal of lipid research · 2014Trial
- Omega-6 polyunsaturated fatty acids and adiposity in the UK Biobank Cohort: a cross-sectional and longitudinal prospective analysis.The British journal of nutrition · 2026Article
- Omega-6 polyunsaturated fatty acids and adiposity in the UK Biobank Cohort: a cross-sectional and longitudinal prospective analysis.medRxiv : the preprint server for health sciences · 2025Article
- Enhancing growth performance in Liangshan black sheep through fermented onion: insights from transcriptomics and metabolomics.Frontiers in veterinary science · 2025Article
- Low expression of ELOVL6 may be involved in fat loss in white adipose tissue of cancer-associated cachexia.Lipids in health and disease · 2024Article
- Effects of Feeding Corn Distillers Dried Grains with Solubles on Muscle Quality Traits and Lipidomics Profiling of Finishing Pigs.Animals : an open access journal from MDPI · 2023Article
- Reducing Dietary Polyunsaturated to Saturated Fatty Acids Ratio Improves Lipid and Glucose Metabolism in Obese Zucker Rats.Nutrients · 2023Article
- The Effect of Orally Administered Δ9-Tetrahydrocannabinol (THC) and Cannabidiol (CBD) on Obesity Parameters in Mice.International journal of molecular sciences · 2023Article
- Ability of high fat diet to induce liver pathology correlates with the level of linoleic acid and Vitamin E in the diet.PloS one · 2023Article
- Regulation of Adipose Tissue Biology by Long-Chain Fatty Acids: Metabolic Effects and Molecular Mechanisms.Journal of obesity & metabolic syndrome · 2022Review
- (Wh)olistic (E)ndocannabinoidome-Microbiome-Axis Modulation through (N)utrition (WHEN) to Curb Obesity and Related Disorders.Lipids in health and disease · 2022Review
- The Endocannabinoids-Microbiota Partnership in Gut-Brain Axis Homeostasis: Implications for Autism Spectrum Disorders.Frontiers in pharmacology · 2022Review
- Effects of endocannabinoids on feed intake, stress response and whole-body energy metabolism in dairy cows.Scientific reports · 2021Article
- Sex-Specific Differences in Lysine, 3-Hydroxybutyric Acid and Acetic Acid in Offspring Exposed to Maternal and Postnatal High Linoleic Acid Diet, Independent of Diet.International journal of molecular sciences · 2021Article
- Anti-nociceptive effect of Arbutus andrachne L. methanolic leaf extract mediated by CB1, TRPV1 and PPARs in mouse pain models.Inflammopharmacology · 2020Article
- Specific shifts in the endocannabinoid system in hibernating brown bears.Frontiers in zoology · 2020Article
- Intake of ω-6 Polyunsaturated Fatty Acid-Rich Vegetable Oils and Risk of Lifestyle Diseases.Advances in nutrition (Bethesda, Md.) · 2020Review
- The effects of dietary fatty acids in the physiological outcomes of maternal high-fat diet on offspring energy homeostasis in mice.Journal of developmental origins of health and disease · 2020Article
- Associations Between Cannabis Use, Abdominal Fat Phenotypes and Insulin Traits.Journal of clinical medicine research · 2020Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 3 countries.
Funding
Abstract
Dietary intake of linoleic acid (LNA, 18:2n-6) has increased dramatically during the 20th century and is associated with greater prevalence of obesity. The endocannabinoid system is involved in regulation of energy balance and a sustained hyperactivity of the endocannabinoid system may contribute to obesity. Arachidonic acid (ARA, 20:4n-6) is the precursor for 2-AG and anandamide (AEA), and we sought to determine if low fat diets (LFD) could be made obesogenic by increasing the endocannabinoid precursor pool of ARA, causing excessive endocannabinoid signaling leading to weight gain and a metabolic profile associated with obesity. Mice (C57BL/6j, 6 weeks of age) were fed 1 en% LNA and 8 en% LNA in low fat (12.5 en%) and medium fat diets (MFD, 35 en%) for 16 weeks. We found that increasing dietary LNA from 1 to 8 en% in LFD and MFD significantly increased ARA in phospholipids (ARA-PL), elevated 2-AG and AEA in liver, elevated plasma leptin, and resulted in larger adipocytes and more macrophage infiltration in adipose tissue. In LFD, dietary LNA of 8 en% increased feed efficiency and caused greater weight gain than in an isocaloric reduction to 1 en% LNA. Increasing dietary LNA from 1 to 8 en% elevates liver endocannabinoid levels and increases the risk of developing obesity. Thus a high dietary content of LNA (8 en%) increases the adipogenic properties of a low fat diet.
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Registered trials
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